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FLASH GENE
Symbol HSPA13 contributors: mct - updated : 20-08-2015
HGNC name heat shock protein 70kDa family, member 13
HGNC id 11375
Location 21q11.2      Physical location : 15.743.438 - 15.755.509
Synonym name
  • microsomal stress 70 protein ATPase core
  • stress 70 protein chaperone, microsome-associated, 60kDa
  • Synonym symbol(s) STCH
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 12.07 kb     5 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked   status confirmed
    Map cen - D21Z1 - STCH - D21S516 - D21S236 - D21S13 - D21S192 - D21S172 - D21S4 - D21S110 - D21S59 - D21S225 - D21S11 - D21S52 - D21S1 - D21S95 - D21S18 - D21S222 - qter
    Authors De Sario (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4001 - 471 - 2000 10675567
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal ATPase domain
  • an unique hydrophobic signal sequence
  • without C-terminal DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY stress 70 chaperone family member
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the processing of cytosolic and secretory proteins
  • Hsp70-like protein, playing a role in regulating cell cycle and cell death events
  • has likely a role in cell survival via modulation of the TRAIL-mediated cell death pathway
  • novel role of HSPA13 in the regulation of pHi through site-specific interactions with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • may play a role in pHi regulation at times of cellular stress by enhancing the recovery from intracellular acidification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is interacting with SLC4A4 at the N-terminal (amino acids 96-440) region
  • site-specific interactions of HSPA13 with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility susceptibility to gastric cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    corresponding disease(s)
    Susceptibility to gastric cancer
    Variant & Polymorphism SNP increasing the risk of gastric cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS