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FLASH GENE
Symbol HSP90AB1 contributors: mct - updated : 23-04-2016
HGNC name heat shock protein 90kDa alpha (cytosolic), class B member 1
HGNC id 5258
Location 6p21.1      Physical location : 44.214.848 - 44.221.614
Synonym name heat shock 90kDa protein 1, beta
Synonym symbol(s) D6S182, HSPC2, HSP90B, HSP90-BETA, HSPCB, HSP84, FLJ26984
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     12 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2567 83.3 724 - 2005 16269234
  • HSP90AB1-1
  • - - 2673 - 714 amygdala 2005 16269234
    HSP90AB1-2
    - - 2642 - 724 colon 2005 16269234
    HSP90AB1-3
    - - 2559 - 676 pancreas 2005 16269234
    HSP90AB1-4
    - - 2716 - 724 - 2005 16269234
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an adenine nucleotide binding site
  • a potential leucine zipper domain between two charged regions
  • a binding site for steroid receptors and for the cochaperone Hop (hsp organizing protein) and hsp23
  • a C terminal dimerization domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • heat shock protein 90 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • molecular chaperone, having ATPase activity
  • involved in signaling prolactin-induced apoptosis through the receptor
  • could be involved in human ovarian autoimmunity and thereby be a causative factor in early ovarian failure
  • potential role for HSP90AB1 in mesenchymal stromal cells biology
  • involved in BCL2-dependent stabilization of HIF-1alpha protein during hypoxia
  • HSP90AA1, HSP90AB1 differentially modulate NO and O(2)(-) generation by eNOS (endothelial nitric oxide synthase) through promoting changes in endothelial nitric oxide synthase conformation and phosphorylation state 3)
  • possible role for HSP90AB1 in postentry HIV replication
  • potential role for this class of cellular chaperones in HIV core stability and uncoating
  • may positively regulate angiogenesis, not only as a protein chaperone, but also as an mRNA stabilizer for pro-angiogenic genes, such as BCL6B, in a PRKD2 activity-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BCAS2 can form a complex with AR and HSP90, it may function with HSP90AB1 to stabilise AR protein from being degraded by proteasome
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • Hsp23 in an ATP dependent manner
  • steroid receptors
  • BIRC2 is a client protein of the stress protein HSP90AB1 (prevents auto-ubiquitination and degradation of BIRC2, whose depletion would be sufficient to inhibit cell differentiation)
  • UNC45A is required for the normal cellular distribution of HSP90AB1, but not HSP90AA1
  • RAF1, HSF1, CDC37, and MAP2K1 interacted with both HSP90AA1 and HSP90AB1, and the relative patterns of these interactions were not affected by heat shock 4)
  • TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with HSP90AB1 and consequently regulates transcription of NANOG in embryonic stem cells
  • HSP90AA1 and HSP90AB1, and not HSP90B1-GRP94 or TRAP1, are responsible for maintaining proper cellular levels of ARNTL protein (r
  • SMYD2-dependent HSP90AB1 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
  • ERBB2 interact with the chaperone, HSP90AB1, and the calcium pump, ATP2B2, within specific plasma membrane domains that protrude from the cell surface
  • cell & other
    REGULATION
    inhibited by caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis
    Other cleaved by activated caspase-10 under UVB irradiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    may provide an attractive target for therapeutic intervention in HIV infection
    ANIMAL & CELL MODELS