Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSH2D contributors: mct - updated : 01-04-2014
HGNC name hematopoietic SH2 domain containing
HGNC id 24920
Location 19p13.12      Physical location : 16.244.837 - 16.269.375
Synonym name
  • adaptor in lymphocytes of unknown function X
  • hematopoietic SH2 protein
  • Synonym symbol(s) ALX, HSH2, FLJ14886
    DNA
    TYPE like-sequence
    STRUCTURE 24.54 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2369 - 352 - 2001 11700021
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    Lymphoid/ImmuneT cell Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • several sites for potential protein-protein interaction
  • an Src homology 2 (SH2) domain
  • four PXXP polyproline sequences
  • two likely sites of tyrosine phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY T-cell-specific adapter (TSAd) proteins family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly localized to the cytoplasm, but partially resides in the nucleus, and the nuclear pool is rapidly depleted in response to T cell receptor (TCR)/CD28 signaling
  • basic FUNCTION
  • adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation
  • SH2D2A and HSH2D are adaptors related by structure and sequence, coexpressed in T cells
  • SH2D2A and HSH2D have nonredundant functions in lymphocytes
  • adapter protein playing key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules
  • changes in HSH2D expression have profound effects on the humoral immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of both TCR and CD28 costimulatory signaling pathways
  • exerts its effect on IL2 up-regulation in the cytoplasm and suggest an intricate relationship between the nuclear localization/export, phosphorylation, and activity of ALX in response to TCR and CD28 signaling
  • cell & other
    REGULATION
    Phosphorylated by although it is inducibly phosphorylated upon TCR/CD28 stimulation, this phosphorylation is not required for HSH2D to inhibit T cell activation
    Other regulated in a dynamic manner during B cell maturation and differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS