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FLASH GENE
Symbol HSF2BP contributors: mct - updated : 07-04-2021
HGNC name heat shock transcription factor 2 binding protein
HGNC id 5226
Corresponding disease
POF19 premature ovarian failure 19
Location 21q22.3      Physical location : 44.949.072 - 45.079.374
Synonym name heat shock factor 2 binding protein
Synonym symbol(s) MEILB2, POF19
DNA
TYPE functioning gene
STRUCTURE 205.51 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1900 37.5 334 - 2020 31960047
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • hydrophilic domain
  • two leucine-zipper motives in alpha helix
  • hydrophobic region with beta-sheets
    • HOMOLOGY
    interspecies ortholog to murine Hsf2bp
    homolog to C.elegans F58F6.4
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulating HSF2 activation in testis
  • HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis
  • directly binds to BRCA2 and regulates its association to meiotic DSBs
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HSF2 (by its trimerization domain), HSF1
  • is a testis-specific binding protein of HSF2, and is a binding partner of BNC1
  • HSF2BP could interact with and inhibit BNC1 transcriptional activity without affecting its expression level
  • BRCA2-HSF2BP interaction is highly evolutionarily conserved and maps to armadillo repeats in HSF2BP and a 68-amino acid region between the BRC repeats and the DNA binding domain of human BRCA2
  • BRME1 functions as a stabilizer of HSF2BP by binding to an alpha-helical N-terminus of HSF2BP and preventing HSF2BP self-association
  • BRME1 modulates localization of recombinases to meiotic double-strand break (DSB)sites through the interaction with the BRCA2/HSF2BP complex during meiotic recombination
  • is a novel recombination factor and probably mediates DMC1/RAD51 recruitment to ssDNA or their stability on chromosomes through physical interaction with HSF2BP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF19
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS