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FLASH GENE

Symbol

HSF2BP

contributors: npt/ - updated : 15-04-2008

HGNC name	heat shock transcription factor 2 binding protein
HGNC id	5226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q22.3      Physical location : 44.949.072 - 45.079.374
Synonym name	heat shock factor 2 binding protein

DNA

TYPE	functioning gene
STRUCTURE	130.30 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HSF2BP 9 - 1916 37.5 334 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic Hydrophobic
STRUCTURE

motifs/domains	hydrophilic domain
	two leucine-zipper motives in alpha helix
	hydrophobic region with beta-sheets

HOMOLOGY

interspecies	ortholog to murine Hsf2bp
	homolog to C.elegans F58F6.4

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

modulating HSF2 activation in testis

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development , reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to HSF2 (by its trimerization domain), HSF1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS