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FLASH GENE
Symbol HSF2BP contributors: npt/ - updated : 15-04-2008
HGNC name heat shock transcription factor 2 binding protein
HGNC id 5226
Location 21q22.3      Physical location : 44.949.072 - 45.079.374
Synonym name heat shock factor 2 binding protein
DNA
TYPE functioning gene
STRUCTURE 130.30 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1916 37.5 334 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • hydrophilic domain
  • two leucine-zipper motives in alpha helix
  • hydrophobic region with beta-sheets
  • HOMOLOGY
    interspecies ortholog to murine Hsf2bp
    homolog to C.elegans F58F6.4
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulating HSF2 activation in testis
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HSF2 (by its trimerization domain), HSF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS