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FLASH GENE
Symbol HSF2 contributors: mct/npt - updated : 19-12-2015
HGNC name heat shock transcription factor 2
HGNC id 5225
Location 6q22.33      Physical location : 122.720.695 - 122.754.264
Synonym name heat shock factor 2
Synonym symbol(s) HSTF2, MGC117376, MGC156196, MGC75048
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 33.57 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
MAPPING cloned Y linked N status provisional
Physical map
C6orf61 6q22.31 chromosome 6 open reading frame 61 ASF1A 6q22.32 ASF1 anti-silencing function 1 homolog A (S. cerevisiae) MCMDC1 6q22.31 minichromosome maintenance deficient domain containing 1 C6orf60 6q22.31 chromosome 6 open reading frame 60 MAN1A1 6q22 mannosidase, alpha, class 1A, member 1 C6orf170 6q22.32 chromosome 6 open reading frame 170 GJA1 6q22.3 gap junction protein, alpha 1, 43kDa (connexin 43) LOC260339 6q22.32 processed pseudogene mtTFA 3 LOC391966 6 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LOC391967 6 similar to 60S ribosomal protein L23a HSF2 6q22.33 heat shock transcription factor 2 TDE2 6q22.32 tumor differentially expressed 2 PKIB 6q22.32 protein kinase (cAMP-dependent, catalytic) inhibitor beta FABP7 6q22-q23 fatty acid binding protein 7, brain SMPDL3A 6q22.32 sphingomyelin phosphodiesterase, acid-like 3A C6orf213 6q22.32 chromosome 6 open reading frame 213 TRDN 6q22-q23 triadin TCBA1 6q21-q22 T-cell lymphoma breakpoint associated target 1 IBRDC1 6q22.33 IBR domain containing 1 TPD52L1 6q22-q23 tumor protein D52-like 1 C6orf74 6q13-q24.3 chromosome 6 open reading frame 74 LOC256096 6q22.33 hypothetical LOC256096 HEY2 6q22.2-q22.33 hairy/enhancer-of-split related with YRPW motif 2 NCOA7 6q22.33 nuclear receptor coactivator 7 HINT3 6q22.33 histidine triad nucleotide binding protein 3 C6orf75 6q11.1-q22.33 chromosome 6 open reading frame 75
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2697 - 536 - 2006 16600913
12 - 2643 - 518 - 2006 16600913
7 - 1088 - 230 - 2006 16600913
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrinepancreas   highly
Hearing/Equilibriumear   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • HSF-type DNA binding domain
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Hsf2
    Homologene
    FAMILY
  • HSF family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cytoplasmic during normal growth and nuclear upon activation
    basic FUNCTION
  • participates in the transcriptional regulation of the heat shock response
  • new role for HSF2 in the regulation of protein degradation
  • playing an important role for constitutive as well as stress-inducible expression of HSE-containing genes
  • plays roles in development of the brain and reproductive organs
  • required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
  • role for HSF2 in the pathogenesis of Idiopathic azoospermia (IA)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • stress-responsive component of the stress granules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SUMO1 (for the conversion of this factor to the active DNA binding form)
  • interact with HSF1 through their trimerization domains (HSF1 influences the DNA binding activity of HSF2, and HSF2 influences to the localization of HSF1 in stress granules)
  • interacting with PCGF2 (interaction with PCGF2 decreases during mitosis, resulting in elevated PCGF2 sumoylation)
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • HSF2 and HSF4 regulate transcription of HIF1A and a critical balance between these HSF is required to maintain HIF1A expression in a repressed state
  • HSF4 inhibits HSF2 expression or transcriptional activity through negative regulation of HSF2 binding to the HSP70 promoter
  • HSF2 could regulate aerobic glycolysis by suppression of FBP1 to support uncontrolled proliferation of hepatocellular carcinoma cells
  • cell & other
    REGULATION
    Other regulated by SUMO1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionfertility 
    potential therapeutic target for idiopathic azoospermia
    ANIMAL & CELL MODELS