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FLASH GENE
Symbol HSDL1 contributors: mct/npt - updated : 07-03-2009
HGNC name hydroxysteroid dehydrogenase like 1
HGNC id 16475
Location 16q24.2      Physical location : 84.155.743 - 84.178.800
Synonym name
  • steroid dehydrogenase-like
  • short chain dehydrogenase/reductase family 12C, member 3
    • Synonym symbol(s) LOC83693, MGC125994, MGC125995, SDR12C3, MGC126032
    DNA
    TYPE functioning gene
    STRUCTURE 22.87 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3488 36.9 330 - Persson (2008)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex  
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Hsdl1
    intraspecies homolog to HSD3
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • 17-beta-HSD 3 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having cysteine-type endopeptidase, oxidoreductase activities
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2008)
  • despite the potential lack of enzymatic activity HSDL1 might retain regulatory functions in the cell (Meier 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS