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FLASH GENE
Symbol HSD17B8 contributors: npt/ - updated : 19-05-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 8
HGNC id 3554
Location 6p21.32      Physical location : 4.404.641 - 33.174.607
Synonym name
  • Ke6 gene, mouse, human homolog of
  • FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E coli) like
  • estradiol 17 beta-dehydrogenase 8
  • testosterone 17-beta-dehydrogenase 8
  • 17-beta-HSD 8
  • Synonym symbol(s) KE6, RING2, H2-KE6, D6S2245E, FABGL, DHB8, SDR30C1, dJ1033B10.9
    EC.number 1.1.1.62, 1.1.1.63
    DNA
    TYPE functioning gene
    STRUCTURE 2.19 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2 HLA-DOA 6p21.3 major histocompatibility complex, class II, DO alpha HLA-DPA1 6p21.3 major histocompatibility complex, class II, DP alpha 1 HLA-DPB1 6p21.3 major histocompatibility complex, class II, DP beta 1 RPL32P1 6p21.3 ribosomal protein L32 pseudogene 1 LOC391913 6 similar to MHC HLA-SX-alpha HLA-DPB2 6p21.3 major histocompatibility complex, class II, DP beta 2 (pseudogene) COL11A2 6p21.3 collagen, type XI, alpha 2 RXRB 6p21.3 retinoid X receptor, beta SLC39A7 6p21.3 solute carrier family 39 (zinc transporter), member 7 HSD17B8 6p21.3 hydroxysteroid (17-beta) dehydrogenase 8 RING1 6p21.3 ring finger protein 1 VPS52 6p21.3 vacuolar protein sorting 52 (yeast) B3GALT4 6p21.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 RPS18 6p21.3 ribosomal protein S18 C6orf11 6p21.3 chromosome 6 open reading frame 11 D6S2723E 6p21.3 DNA segment on chromosome 6 (unique, pseudogene) 2723 expressed sequence HKE2 6p21.3 HLA class II region expressed gene KE2 RAB2L 6p21.3 RAB2, member RAS oncogene family-like TAPBP 6p21.3 TAP binding protein (tapasin) ZNF297 6p21.3 zinc finger protein 297 DAXX 6p21.3 death-associated protein 6 LOC346177 6p21.31 similar to myosin:SUBUNIT=regulatory light chain LYPLA2P1 6p21.31 lysophospholipase II pseudogene 1 KIFC1 6p21.3 kinesin family member C1 PHF1 6p21.3 PHD finger protein 1 C6orf82 6pter-p21.31 chromosome 6 open reading frame 82
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 989 27 261 - Persson (2009)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ke6
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • using estradiol as its preferred substrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    estrogen biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS