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FLASH GENE
Symbol HSD17B13 contributors: mct/npt - updated : 10-06-2009
HGNC name hydroxysteroid (17-beta) dehydrogenase 13
HGNC id 18685
Location 4q22.1      Physical location : 88.224.940 - 88.244.056
Synonym name
  • short-chain dehydrogenase/reductase 9
  • 17-beta hydroxysteroid dehydrogenase 13 precursor
  • short chain dehydrogenase/reductase family 16C, member 3
    • Synonym symbol(s) SCDR9, HMFN0376, NIIL497, SDR16C3, HMFN0376, MGC138508, MGC138510
    EC.number 1.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 19.10 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2395 33.5 300 - Liu (2007)
    - - 2287 29.5 264 - Liu (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide sequence
  • an ADH_short domain
    • HOMOLOGY
    interspecies homolog to murine Hsd17b13 (82.7pc)
    homolog to rattus Hsb17b13 (81.0pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • secreted protein
  • concentrated in some site of the cytoplasm, but not in the ER (Liu 2009)
    • basic FUNCTION
  • may have an oxidoreductase activity
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS