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FLASH GENE
Symbol HSD17B12 contributors: mct/npt - updated : 15-04-2008
HGNC name hydroxysteroid (17-beta) dehydrogenase 12
HGNC id 18646
Location 11p11.2      Physical location : 43.702.142 - 43.878.160
Synonym name
  • 3-ketoacyl-CoA reductase
  • steroid dehydrogenase homolog
  • likely ortholog of mouse Kik1 steroid dehydrogenase
  • Synonym symbol(s) KAR
    EC.number 1.1.1.62, 1.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 176.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387761 11 LOC387761 LOC120448 11p11.2 similar to heterogeneous nuclear ribonucleoprotein K API5 11p12-q12 apoptosis inhibitor 5 FLJ10890 LOC120449 11p11.2 similar to CTBP2 protein LOC143970 11p11.2 hypothetical LOC143970 LOC387762 11 LOC387762 HSD17B12 11p11.2 hydroxysteroid (17-beta) dehydrogenase 12 DEPC-1 11p11.2 prostate cancer antigen-1 LOC387763 11 hypothetical gene supported by BC052560 LOC390110 11 similar to 1-aminocyclopropane-1-carboxylate synthase PHACS 11p11 1-aminocyclopropane-1-carboxylate synthase EXT2 11p12-p11.2 exostoses (multiple) 2 ALX4 11p11.2 aristaless-like homeobox 4 LOC390111 11 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) KAI1 11p11.2-p11.13 kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) LOC387764 11 LOC387764 LOC90139 11p11.2 tetraspanin similiar to uroplakin 1 TP53I11 11pter-p15.5 tumor protein p53 inducible protein 11 PRDM11 11p11 PR domain containing 11 LOC219638 11p11.2 similar to KIAA0543 protein SYT13 11p12-p11 synaptotagmin XIII CHST1 11p11.2-p11.1 carbohydrate (keratan sulfate GAL-6) sulfotransferase 1 DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2556 34.3 312 - Sakurai (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane domains
  • dilysin ER retention motif
  • HOMOLOGY
    interspecies homolog to Drosophila CG1444
    homolog to C.elegans C56G2.6
    Homologene
    FAMILY
  • short chain dehydrogenase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • transforming estrone (E1) into estradiol (E2)
  • having a 3-ketoacylCoA reductase activity
  • may playing a critical roles in the physiological processes, such as fatty acid synthesis, in addition to the steroid metabolism
  • major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women, especially in the ovary, the predominant source of estrogens before menopause
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    long chain fatty acid elongation
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS