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FLASH GENE
Symbol HS6ST2 contributors: mct - updated : 04-04-2012
HGNC name heparan sulfate 6-O-sulfotransferase 2
HGNC id 19133
Location Xq26.2      Physical location : 131.760.037 - 132.095.423
Synonym symbol(s) RP3-435D1.3
EC.number 2.8.2.-
DNA
TYPE functioning gene
STRUCTURE 335.39 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ11362 Xq25-q26.1 hypothetical protein FLJ11362 ELF4 Xq26 E74-like factor 4 (ets domain transcription factor) PDCD8 Xq25-q26 programmed cell death 8 (apoptosis-inducing factor) RAB33A Xq26.1 RAB33A, member RAS oncogene family FLJ20095 Xq26.1 hypothetical protein FLJ20095 SLC25A14 Xq24 solute carrier family 25 (mitochondrial carrier, brain), member 14 GPR119 Xq26.1 G protein-coupled receptor 119 CGI-79 Xq26.3-q27.3 G protein-coupled receptor 119 HT011 Xq26.1 uncharacterized hypothalamus protein HT011 COVA1 Xq25-q26.2 cytosolic ovarian carcinoma antigen 1 FLJ30058 Xq26.1 hypothetical protein FLJ30058 IGSF1 Xq25 immunoglobulin superfamily, member 1 LOC392540 X similar to olfactory receptor GA_x6K02T2Q64A-11927171-11926215 LOC392541 X similar to olfactory receptor MOR216-1 OR1AA1P Xq26.2 olfactory receptor, family 1, subfamily AA, member 1 pseudogene LOC392542 X similar to NACHT, leucine rich repeat and PYD containing 7; PYRIN-containing Apaf1-like protein 3; NACHT, LRR and PYD containing protein 7 LOC347468 Xq26.2 similar to Olfactory receptor 13H1 OR7L1P Xq26.2 olfactory receptor, family 7, subfamily L, member 1 pseudogene OR2AF2P Xq26.2 olfactory receptor, family 2, subfamily AF, member 2 pseudogene LOC389886 X similar to hypothetical protein MGC15416 MST4 Xq26.1 similar to hypothetical protein MGC15416 LOC90167 Xq26.2 hypothetical protein LOC90167 LOC392543 X similar to hypothetical protein FLJ10842 RAP2C Xq25 RAP2C, member of RAS oncogene family MBNL3 Xq26.2 muscleblind-like 3 (Drosophila) HS6ST2 Xq26.1-q26.2 heparan sulfate 6-O-sulfotransferase 2 USP26 Xq26.2 ubiquitin specific protease 26 LOC51270 Xq26.2 E2F-like protein GPC4 Xq26.1 glypican 4 GPC3 Xq26.1 glypican 3 LOC347475 Xq26.3 hypothetical gene supported by BC017958 LOC392544 X hypothetical gene supported by NM_152729 PHF6 Xq26 PHD finger protein 6 HPRT1 Xq26.1 hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) MGC16121 Xq26.3 hypothetical protein MGC16121 PLAC1 Xq26 placenta-specific 1 LOC159090 Xq26.3 similar to hypothetical protein MGC17347 LOC159091 Xq26.3 hypothetical protein BC017868 DJ473B4 Xq26.3 hypothetical protein dJ473B4 LOC340581 Xq26.3 hypothetical protein LOC340581 LOC392545 X similar to high mobility group protein homolog HMG4 LOC389887 X similar to RIKEN cDNA 1110012O05 CXX1 Xq26 CAAX box 1 DKFZP564B147 Xq26.3 DKFZP564B147 protein LOC159049 Xq26.3 hypothetical LOC159049 FLJ20527 Xq26.3 hypothetical protein FLJ20527 LOC392546 X similar to hypothetical protein FLJ20527 LOC389888 X similar to hypothetical protein FLJ20527
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4576 - 645 - 2003 12492399
  • variant L
  • 4 - 4456 - 605 - 2003 12492399
  • variant S
  • - - 2564 - 459 - 2003 12492399
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY sulfotransferase 6 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the synthesis of heparan sulfates with tissue-specific structures and functions
  • potentiates Notch signalling in pancreatic cancer cells
  • may participate in the pathogenesis of osteoarthritis and Kashin-Beck disease by influencing aggrecan metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of chondrocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    could be an attractive target for pancreas cancer therapy
    ANIMAL & CELL MODELS