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FLASH GENE
Symbol HS3ST4 contributors: npt/ - updated : 03-10-2007
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 4
HGNC id 5200
Location 16p12.1      Physical location : 25.703.346 - 26.149.008
Synonym name heparan sulfate 3-O-sulfotransferase 4
Synonym symbol(s) 3OST4, 30ST4, 3-OST-4
EC.number 2.8.2.23
DNA
TYPE functioning gene
STRUCTURE 390.58 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3203 49.7 456 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four domains
  • a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain, acting as a flexible stem)
  • a conserved C terminal catalytic sulfotransferase domain
    • HOMOLOGY
    interspecies homolog to murine Hs3st4
    homolog to Drosophila CG7890
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 4
  • putative regulator of heparan sulfate proteoglycan properties
  • playing a role in the generation of heparan sulfate proteoglycan
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS