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FLASH GENE
Symbol HS3ST3B1 contributors: npt/ - updated : 03-10-2007
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
HGNC id 5198
Location 17p12      Physical location : 14.204.505 - 14.249.492
Synonym name heparan sulfate 3-O-sulfotransferase 3B1
Synonym symbol(s) 3OST3B1, 30ST3B1, HS3ST3B, h3-OST-3B
EC.number 2.8.2.30
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2032 43.2 390 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta (predominantly)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four domains,a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain, acting as a flexible stem)
  • a putative C terminal catalytic domain
    • HOMOLOGY
    interspecies homolog to murine Hs3st3b
    homolog to Drosophila CG7890
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1
  • putative regulator of heparan sulfate proteoglycan properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS