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FLASH GENE
Symbol HS3ST2 contributors: mct - updated : 28-08-2015
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HGNC id 5195
Location 16p12      Physical location : 22.825.859 - 22.927.657
Synonym name
  • heparin-glucosamine 3-O-sulfotransferase
  • heparan sulfate 3-O-sulfotransferase 2
  • Synonym symbol(s) 3OST2, 30ST2, h3-OST-2
    EC.number 2.8.2.29, 2.8.2.23
    DNA
    TYPE functioning gene
    STRUCTURE 101.80 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1968 41.4 367 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   predominantly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five potential N-glycosylation sites
  • four domains
  • a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain, acting as a flexible stem)
  • a putative C terminal conserved sulfotransferase domain
  • HOMOLOGY
    interspecies homolog to murine Hs3st2
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 2
  • putative regulator of heparan sulfate proteoglycan properties
  • may play a role in the nervous system development
  • involved in glycosaminoglycan chain synthesis or modifications
  • HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS