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FLASH GENE

Symbol

HS3ST2

contributors: mct - updated : 28-08-2015

HGNC name	heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HGNC id	5195

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p12      Physical location : 22.825.859 - 22.927.657
Synonym name	heparin-glucosamine 3-O-sulfotransferase
	heparan sulfate 3-O-sulfotransferase 2
Synonym symbol(s)	3OST2, 30ST2, h3-OST-2
EC.number	2.8.2.29, 2.8.2.23

DNA

TYPE	functioning gene
STRUCTURE	101.80 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HS3ST2 2 - 1968 41.4 367 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain       predominantly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five potential N-glycosylation sites
	four domains
	a N terminal cytoplasmic tail
	an hydrophobic transmembrane segment
	a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain, acting as a flexible stem)
	a putative C terminal conserved sulfotransferase domain

HOMOLOGY

interspecies	homolog to murine Hs3st2
	homolog to C.elegans hst-3

Homologene

FAMILY

sulfotransferase 1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi
text	integral membrane protein type II

basic FUNCTION	heparan sulfate D-glucosamine 3-O-sulfotransferase 2
	putative regulator of heparan sulfate proteoglycan properties
	may play a role in the nervous system development
	involved in glycosaminoglycan chain synthesis or modifications
	HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS