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FLASH GENE
Symbol HRH4 contributors: - updated : 19-07-2007
HGNC name histamine receptor H4
HGNC id 17383
Location 18q11.2      Physical location : 22.040.592 - 22.059.920
Synonym name
  • G-protein coupled receptor 105
  • Synonym symbol(s) BG26, HH4R, GPRV53, SP9144, H4, H4R, AXOR35, GPCR105
    DNA
    TYPE functioning gene
    STRUCTURE 19.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     liver   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   lowly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies homolog to chimpanzee HRH4 (98.7 pc)
    homolog to rattus Hrh4 (69.9 pc)
    homolog to murine Hrh4 (68.9 pc)
    intraspecies homolog to HRH3
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • could mediate the histamine signals in peripheral tissues
  • acting as an histamine receptor
  • acting as a rhodopsin-like receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL-10 or IL-13
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS