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FLASH GENE
Symbol HPCAL1 contributors: npt/ - updated : 21-04-2008
HGNC name hippocalcin-like 1
HGNC id 5145
Location 2p25.1      Physical location : 10.443.039 - 10.567.742
Synonym name
  • visinin-like protein 3
  • calcium-binding protein BDR-1
    • Synonym symbol(s) HPCAL, BDR1, HLP2, VILIP-3
    DNA
    TYPE functioning gene
    STRUCTURE 124.70 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1769 22.2 193 - -
  • utilizing a different exon and also lacking one exon in the 5' UTR
  • encoded protein is the same
    • - splicing 1920 22.2 193 - -
  • utilizing an alternative exon of 243 bases instead of exon 1 and containing an additional exon of 173 bases in the 5' UTR
  • encoding the same protein
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine hippocalcin like-1
    homolog to rattus hippocalcin like-1
    homolog to Drosophila Nca
    homolog to C.elegans ncs-3
    intraspecies homolog to hippocalcin
    Homologene
    FAMILY
  • neuron-specific calcium-binding proteins family
  • recoverin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in the calcium-dependent regulation of rhodopsin phosphorylation
  • may be of relevance for neuronal signaling in the central nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to actin, tubulin, clathrin
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS