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FLASH GENE
Symbol HOXD3 contributors: mct/npt - updated : 22-12-2009
HGNC name homeo box D3
HGNC id 5137
Location 2q31.1      Physical location : 177.028.804 - 177.037.826
Synonym name
  • homeo box D3(4A)
  • homeobox protein Hox-D3
  • Hox-4.1, mouse, homolog of
    • Synonym symbol(s) HOX4A, HOX4, HOX1D, MGC10470
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 9.02 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HOXD@
    Physical map
    KIAA1715 2q31 KIAA1715 LOC344191 2q31.2 similar to Homeobox even-skipped homolog protein 2 (EVX-2) HOXD13 2q31 homeo box D13 HOXD12 2q31 homeo box D12 HOXD11 2q31.1 homeo box D11 HOXD10 2q31 homeo box D10 HOXD9 2q31 homeo box D9 HOXD8 2q31 homeo box D8 HOXD4 2q31 homeo box D4 HOXD3 2q31 homeo box D3 HOXD1 2q31-q37 homeo box D1 LOC150978 2q31.2 similar to 60S acidic ribosomal protein P1 LOC129841 2q31.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MTX2 2q24.3-q31 metaxin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2319 - 432 - Chen (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     female systembreast   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.1
    homolog to Drosophila Zen
    Homologene
    FAMILY
  • ANTP homeobox family
    • CATEGORY adhesion , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in the regulation of cell adhesion processes
  • potent proangiogenic transcription factor that promotes angiogenesis by modulating the expression of matrix-degrading proteinases, integrins, and extracellular matrix components (Chen 2004)
  • may play an important role in regulating cerebral angiogenesis (Chen 2004)
  • may be playing a role in scarless wound repair (Jain 2008)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis (Chen 2004)
    ANIMAL & CELL MODELS
    Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin (Jain 2008)