Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

HOXC9

contributors: mct - updated : 27-11-2010

HGNC name	homeo box C9
HGNC id	5130

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.13      Physical location : 54.393.876 - 54.397.118
Synonym name	homeobox protein Hox-3B
	homeobox protein Hox-C9
Synonym symbol(s)	HOX3B, HOX3

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	3.24 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXC@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006897 2 - 1640 NP_008828 - 260 - 2007 17588684

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed throughout the E9.5 forelimb bud

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-3.2
	homolog to Drosophila abd-B

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in mouse posterior limb patterning
	has an essential role in organizing the motor system through global repressive activities
	required for the generation of thoracic motor columns, and in its absence, neurons acquire the fates of limb-innervating populations

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction between the recombinant homeodomain (HD) of HOXC9 and MH1 domain of SMAD4

cell & other

REGULATION

inhibited by

SMAD4 (SMAD4 inhibits HOXC9 transcription activity)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS