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FLASH GENE
Symbol HOXC5 contributors: mct - updated : 24-02-2015
HGNC name homeo box C5
HGNC id 5127
Location 12q13.13      Physical location : 54.410.641 - 54.429.142
Genatlas name homeo box C5(3D)
Synonym name
  • homeobox protein CP11
  • homeobox protein Hox-3D
  • Synonym symbol(s) HOX3D, CP11, HOX3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 18.51 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Map see HOXC@
    Physical map
    HOXC13 12q13.3 homeo box C13 HOXC12 12q13.3 homeo box C12 HOXC11 12q13.3 homeo box C11 HOXC10 12q13.3 homeo box C10 HOXC9 12q13.3 homeo box C9 HOXC8 12q13.3 homeo box C8 HOXC4 12q13.3 homeo box C4 HOXC6 12q13.3 homeo box C6 HOXC5 12q13.3 homeo box C5 LOC387863 12 LOC387863 SMUG1 12q13.11-q13.3 single-strand selective monofunctional uracil DNA glycosylase CBX5 12q12 chromobox homolog 5 (HP1 alpha homolog, Drosophila) HNRPA1 12q13.1 heterogeneous nuclear ribonucleoprotein A1 NFE2 12q13.1-q13.2 nuclear factor (erythroid-derived 2), 45kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2081 - 153 - -
    2 - 1681 - 235 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text first trimester trophoblast,anterior limb
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    helix-turn-helix,DNA binding domain
    HOMOLOGY
    interspecies homolog to murine Hox-3.4
    homolog to Drosophila antp,Ubx,abd-A
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mouse anterior limb patterning
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • is required for forelimb anterior patterning
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS