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FLASH GENE
Symbol HOXC5 contributors: mct - updated : 24-02-2015
HGNC name homeo box C5
HGNC id 5127
Location 12q13.13      Physical location : 54.410.641 - 54.429.142
Genatlas name homeo box C5(3D)
Synonym name
  • homeobox protein CP11
  • homeobox protein Hox-3D
    • Synonym symbol(s) HOX3D, CP11, HOX3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 18.51 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Map see HOXC@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2081 - 153 - -
    2 - 1681 - 235 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text first trimester trophoblast,anterior limb
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		helix-turn-helix,DNA binding domain
    HOMOLOGY
    interspecies homolog to murine Hox-3.4
    homolog to Drosophila antp,Ubx,abd-A
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mouse anterior limb patterning
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • is required for forelimb anterior patterning
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS