Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HOXB8 contributors: - updated : 23-01-2006
HGNC name homeo box B8
HGNC id 5119
Location 17q21.3      Physical location : 46.689.708 - 46.692.301
Synonym name homeo box B8(2D)
Synonym symbol(s) HOX2D, HOX2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text included in a cluster of homeobox B genes
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
Map see HOXB@
Physical map
HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one homeobox DNA-binding domain
HOMOLOGY
interspecies homolog to Drosophila Antp,Ubx,abd-A
ortholog to murine Hoxb8
Homologene
FAMILY Antp homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • functions as a sequence-specific transcription factor that is involved in development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by miRNA-196 upstream the SHH negative feedback loop
    Other controlled by SHH through a negative feedback loop
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression of the gene is associated with colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Hoxb8 knocked-out mice exhibit an excessive pathologic grooming behavior, that is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania