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FLASH GENE
Symbol HOXB8 contributors: mct - updated : 17-04-2020
HGNC name homeo box B8
HGNC id 5119
Location 17q21.32      Physical location : 46.689.708 - 46.692.301
Synonym name homeo box B8(2D)
Synonym symbol(s) HOX2D, HOX2, Hox-2.4
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text included in a cluster of homeobox B genes
STRUCTURE 7.19 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see HOXB@
Physical map
HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2176 - 243 - 2017 27761656
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one homeobox DNA-binding domain
HOMOLOGY
interspecies homolog to Drosophila Antp,Ubx,abd-A
ortholog to murine Hoxb8
Homologene
FAMILY Antp homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • functions as a sequence-specific transcription factor that is involved in development
  • HOXB8 acts by maintaining noradrenergic properties transiently expressed in ciliary neuron progenitors during normal development
  • HOXB8, a member of the homeobox family,is a crucial contributor to the aggressiveness of Glioblastoma multiforme (GBM)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • HOXB8 regulates expression of microRNAs to control cell death and differentiation
  • HOXB8 neutrophils replicate FCGR and integrin-induced neutrophil signaling and functions
  • HOXB8 genes may play an important role in the GSK3B-mediated osteoblast apoptosis process
  • HOXB8 interacted with a key metastasis regulator BACH1 and instigated BACH1-mediated transcriptional cascade by directly occupying and activating BACH1 gene transcription together with BACH1 itself
  • HOXB8 is crucial for the activation of the PI3K/AKT pathway and expression of epithelial-mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 and activating its transcription
  • cell & other
    REGULATION
    repressed by miRNA-196 upstream the SHH negative feedback loop
    Other controlled by SHH through a negative feedback loop
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression of the gene is associated with colorectal cancer
    tumoral     --over  
    in the tumor tissue of Glioblastoma multiforme (GBM) patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rat
    tumoral     --over  
    in osteosarcoma tissues and cell lines
    tumoral     --other  
    HOXB8 expression is associated with shorter survival in metastatic ovarian serous carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • HOXB8 may be an independent prognostic factor in Colorectal cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    may represent a novel therapeutic target for the treatment of Osteosarcoma
    ANIMAL & CELL MODELS
  • Hoxb8 knocked-out mice exhibit an excessive pathologic grooming behavior, that is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania
  • adult mice with an Lmx1b loss restricted to Hoxb8 neurons have nociception defects and disrupted organization of primary sensory afferent axons innervating the dorsal horn