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FLASH GENE
Symbol HOXB8 contributors: mct - updated : 17-04-2020
HGNC name homeo box B8
HGNC id 5119
Location 17q21.32      Physical location : 46.689.708 - 46.692.301
Synonym name homeo box B8(2D)
Synonym symbol(s) HOX2D, HOX2, Hox-2.4
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text included in a cluster of homeobox B genes
STRUCTURE 7.19 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see HOXB@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2176 - 243 - 2017 27761656
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one homeobox DNA-binding domain
HOMOLOGY
interspecies homolog to Drosophila Antp,Ubx,abd-A
ortholog to murine Hoxb8
Homologene
FAMILY Antp homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • functions as a sequence-specific transcription factor that is involved in development
  • HOXB8 acts by maintaining noradrenergic properties transiently expressed in ciliary neuron progenitors during normal development
  • HOXB8, a member of the homeobox family,is a crucial contributor to the aggressiveness of Glioblastoma multiforme (GBM)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • HOXB8 regulates expression of microRNAs to control cell death and differentiation
  • HOXB8 neutrophils replicate FCGR and integrin-induced neutrophil signaling and functions
  • HOXB8 genes may play an important role in the GSK3B-mediated osteoblast apoptosis process
  • HOXB8 interacted with a key metastasis regulator BACH1 and instigated BACH1-mediated transcriptional cascade by directly occupying and activating BACH1 gene transcription together with BACH1 itself
  • HOXB8 is crucial for the activation of the PI3K/AKT pathway and expression of epithelial-mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 and activating its transcription
    • cell & other
    REGULATION
    repressed by miRNA-196 upstream the SHH negative feedback loop
    Other controlled by SHH through a negative feedback loop
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression of the gene is associated with colorectal cancer
    tumoral     --over  
    in the tumor tissue of Glioblastoma multiforme (GBM) patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rat
    tumoral     --over  
    in osteosarcoma tissues and cell lines
    tumoral     --other  
    HOXB8 expression is associated with shorter survival in metastatic ovarian serous carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • HOXB8 may be an independent prognostic factor in Colorectal cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    may represent a novel therapeutic target for the treatment of Osteosarcoma
    ANIMAL & CELL MODELS
  • Hoxb8 knocked-out mice exhibit an excessive pathologic grooming behavior, that is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania
  • adult mice with an Lmx1b loss restricted to Hoxb8 neurons have nociception defects and disrupted organization of primary sensory afferent axons innervating the dorsal horn