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FLASH GENE

Symbol

HOXB7

contributors: mct/npt - updated : 26-08-2015

HGNC name	homeobox B7
HGNC id	5118

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.32      Physical location : 46.684.602 - 46.688.383
Synonym name	homeo box B7(2C)
	homeo box c1 protein
Synonym symbol(s)	HOX2C, HOX2, HHOC1, HOX2C, Hox-2.3

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	3.79 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site   silencer   transcription factor
text structure	two potential Sp1/ sp3 binding sites (-1228 and -46)
	two canconical E-boxes, specific for USF-1 (-52 and -38)
	an inverted CCAAT box located at nucleotide -69, that could bind NF-Y and YY1 factors
	TATA-less promoter

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXB@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004502 2 - 1377 NP_004493 - 217 - 2007 17308091

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Endocrine pancreas         Nervous brain         Reproductive female system uterus cervix   highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte

cell lineage
cell lines	in A375 melanoma cell line
fluid/secretion

at STAGE

physiological period

Text	during early myelopoiesis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal octapeptide domain
	helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-2.3
	homolog to Drosophila Antp,Ubx,abd-A

Homologene

FAMILY

Antp homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	regulation of a variety of proangiogenic stimuli (direct role in tumor progression)
	part of a developmental regulatory system that provides cell with specific positional identities on the antero-posterial axis
	having a a function in promoting tumor invasion through activation of Ras/Rho pathway by up-regulating FGF2, a known transcriptional target of HOXB7
	involved in DNA double-strand break repair
	regulates the expression of TALE HOX cofactors by increasing PBX2 and PREP1 and decreasing PBX1
	plays an important role in the development and progression of human colorectal cancer
	polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7
	promote cell proliferation, angiogenesis, epithelial-mesenchymal transition

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	interaction of HOXB7 with PARP1 that involves the homeodomain of HOXB7 and the first zinc finger domain of PARP1
	HOXB7 promotes tumor progression in a cell-autonomous and non-cell-autonomous manner through activation of the TGFb2 signaling pathway

cell & other

REGULATION

Other

transcriptionnaly regulated by Sp1/Sp3, NF-Y, YY1, and USF1 transcription factors

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   caused epithelial-mesenchymal transition in epithelial cells, accompanied by acquisition of aggressive properties of tumorigenicity, migration, and invasion tumoral     --over   associated with poor clinical outcomes, correlating significantly with a short survival time in patients who had lung adenocarcinoma

Susceptibility

To Neural tube defects (NTD)

Variant & Polymorphism other	HOXB7 hypomethylation is a risk factor for NTDs

Candidate gene
Marker	is a valuable marker of colorectal carcinoma prognosis
Therapy target
	System Type Disorder Pubmed cancer lung   could be a novel target for treatment of lung adenocarcinoma patients

ANIMAL & CELL MODELS