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FLASH GENE
Symbol HOXB6 contributors: - updated : 03-02-2007
HGNC name homeo box B6
HGNC id 5117
Location 17q21.3      Physical location : 46.673.098 - 46.682.334
Synonym name homeo box B6(2B)
Synonym symbol(s) HOX2B , HOX2, HU-2,
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 9.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see HOXB@
Physical map
HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1679 - 224 - Sawcer
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Nervousnervespinal nervesciatic  
Reproductivefemale systemuterus  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
Text during early myelopoiesis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-2.2
homolog to Drosophila Antp,Ubx,abd-A
Homologene
FAMILY ANTP homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • required for normal granulopoiesis and monocytopoiesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia
    Susceptibility to hypospadias
    Variant & Polymorphism other polymorphism increasing the risk of hypospadias
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS