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FLASH GENE

Symbol

HOXB6

contributors: - updated : 03-02-2007

HGNC name	homeo box B6
HGNC id	5117

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.3      Physical location : 46.673.098 - 46.682.334
Synonym name	homeo box B6(2B)
Synonym symbol(s)	HOX2B , HOX2, HU-2,

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	9.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see HOXB@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HOXB6 I1 - - 1679 - 224 - Sawcer

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous nerve spinal nerve sciatic     Reproductive female system uterus     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

Text	during early myelopoiesis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-2.2
	homolog to Drosophila Antp,Ubx,abd-A

Homologene

FAMILY

ANTP homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	required for normal granulopoiesis and monocytopoiesis

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia

Susceptibility

to hypospadias

Variant & Polymorphism other	polymorphism increasing the risk of hypospadias

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS