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FLASH GENE
Symbol HOXB2 contributors: mct - updated : 24-08-2012
HGNC name homeobox B2
HGNC id 5113
Location 17q21.32      Physical location : 46.620.020 - 46.622.393
Synonym name
  • K8 home protein
  • homeo box 2H
    • Synonym symbol(s) HOX2H, HOX2, Hox-2.8, K8
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text one of several homeobox HOXB genes located in a cluster on chromosome 17
    STRUCTURE 2.37 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HOXB@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1614 - 356 - 2003 12802276
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Nervousnervecranial nerve   
     nervespinal nervesciatic  
    Visualeyeuvea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-2.8
    homolog to Drosophila pb
    Homologene
    FAMILY
  • ANTP homeobox family
  • proboscipedia subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • regulator of tumor growth in breast cancer
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target for regulation by PLZF in the developing CNS
    • cell & other
    REGULATION
    induced by retinoic acid which requires actin polymerization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopic expression of HOXB2 associated with a poor prognosis for all patients with pancreatic cancer
    tumoral     --over  
    in lung adenocarcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic indicator for stage I lung adenocarcinomas
    • Therapy target
    ANIMAL & CELL MODELS