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FLASH GENE
Symbol HOXB13 contributors: mct/npt/pgu - updated : 22-04-2010
HGNC name homeobox B13
HGNC id 5112
Location 17q21.32      Physical location : 46.802.128 - 46.806.111
Synonym symbol(s) HXBD, PSGD
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 3.99 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see HOXB@
Physical map
HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 FLJ13855 17q21.33 hypothetical protein FLJ13855 EAP30 17q21.33 EAP30 subunit of ELL complex
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3047 - 284 - 2007 17942676
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate  predominantly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text during embryogenesis, robustly expressed in the posterior axial skeleton as well as the posterior endoderm that gives rise to the most distal regions of the gastrointestinal tract and the urogentital sinus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix DNA binding domain
  • HOMOLOGY
    interspecies homolog to murine Hoxb13
    Homologene
    FAMILY
  • ABD-B homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in fetal skin development and cutaneous regeneration
  • may play an important role in tumors arising from endocrine-responsive organs
  • functions as an AR repressor to modulate the complex AR signaling and subsequent growth regulation of prostate cancer cells
  • with the androgen receptor (AR), plays a critical role in the normal development of the prostate gland
  • homeobox transcription factor gene that is important in prostate development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the DNA-binding domain of AR and inhibits the transcription of genes that contain an androgen-response element (ARE)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial, ovarian, and cervical carcinomas and is associated with the invasiveness of ovarian and endometrial cancer cells
    tumoral     --low  
    by hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients
    Susceptibility to hereditary prostate cancer
    Variant & Polymorphism other
  • HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS