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FLASH GENE
Symbol HOXA4 contributors: - updated : 03-02-2007
HGNC name homeo box A4
HGNC id 5105
Location 7p15-p14      Physical location : 27.168.126 - 27.170.399
Genatlas name homeo box A4(1D)
Synonym name Dfd-like protein
Synonym symbol(s) HOX1D, HXA4, HOX1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see HOXA@
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Nervousbrain    
Reproductivemale systemtestis  highly
Respiratorylung    
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text pregnant uterus, heart, nervous system
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-1.4
homolog to Drosophila Dfd
Homologene
FAMILY ANTP homeobox family, deformed subfamily
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypospadias
    • Variant & Polymorphism other
  • polymorphism increasing the risk of hypospadias
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS