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FLASH GENE
Symbol HOXA4 contributors: - updated : 03-02-2007
HGNC name homeo box A4
HGNC id 5105
Location 7p15-p14      Physical location : 27.168.126 - 27.170.399
Genatlas name homeo box A4(1D)
Synonym name Dfd-like protein
Synonym symbol(s) HOX1D, HXA4, HOX1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see HOXA@
Physical map
LOC392006 7 similar to Rpl7a protein SND1 7q31.3 similar to Rpl7a protein LOC346416 7p15.2 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) LOC221875 7p15.2 similar to tropomyosin 3 LOC392007 7 similar to nucleolar protein family A, member 2; component of the H/ACA snoRNP HOXA1 7p15.3 homeo box A1 HOXA2 7p15.3 homeo box A2 HOXA3 7p15.3 homeo box A3 LOC392647 7 similar to mKIAA0038 protein LOC392879 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 HOXA4 7p15.3 homeo box A4 HOXA5 7p15.3 homeo box A5 HOXA6 7p15.3 homeo box A6 LOC392880 7 similar to hypothetical protein MGC2574 HOXA7 7p15.3 homeo box A7 HOXA9 7p15.3 homeo box A9 HOXA10 7p15.3 homeo box A10 HIBADH 7p15.2 3-hydroxyisobutyrate dehydrogenase HOXA11 7p15.3 homeo box A11 HOXA11S 7p15.2 homeo box A11, antisense HOXA13 7p15.3 homeo box A13 EVX1 7p15-p14 eve, even-skipped homeo box homolog 1 (Drosophila) LOC392008 7 similar to 60S ribosomal protein L35 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Nervousbrain    
Reproductivemale systemtestis  highly
Respiratorylung    
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text pregnant uterus, heart, nervous system
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-1.4
homolog to Drosophila Dfd
Homologene
FAMILY ANTP homeobox family, deformed subfamily
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypospadias
  • Variant & Polymorphism other
  • polymorphism increasing the risk of hypospadias
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS