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FLASH GENE

Symbol

HOXA3

contributors: mct - updated : 22-08-2011

HGNC name	homeo box A3
HGNC id	5104

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p15.3      Physical location : 27.145.809 - 27.166.639
Genatlas name	homeo box A3(1E)
Synonym symbol(s)	HOX1 , HXA3

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	20.83 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map

see HOXA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030661 3 - 3258 - 443 - 2011 21170035 NM_153631 4 - 3396 - 443 - 2011 21170035 HOXA3 V3 - - 2774 - 285 - McAlpine

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta       Reproductive male system prostate       Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix,DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-1.5
	homolog to Drosophila Zen1,Zen2

Homologene

FAMILY

ANTP homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds
	apical regulator of haemogenic endothelium

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS