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FLASH GENE
Symbol HOXA11 contributors: mct - updated : 02-02-2011
HGNC name homeobox A11
HGNC id 5101
Corresponding disease
RUSAT radio-ulnar synostosis with amegakaryocytic thrombocytopenia
Location 7p15.2      Physical location : 27.220.776 - 27.224.835
Synonym name homeo box A11 (1I)
Synonym symbol(s) HOX1I, HOX1, RSAT
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • homeobox gene A cluster
  • STRUCTURE 4.06 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    text structure polyalamine stretch in exon 1
    MAPPING cloned Y linked N status confirmed
    Map see HOXA@
    Physical map
    LOC392006 7 similar to Rpl7a protein SND1 7q31.3 similar to Rpl7a protein LOC346416 7p15.2 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) LOC221875 7p15.2 similar to tropomyosin 3 LOC392007 7 similar to nucleolar protein family A, member 2; component of the H/ACA snoRNP HOXA1 7p15.3 homeo box A1 HOXA2 7p15.3 homeo box A2 HOXA3 7p15.3 homeo box A3 LOC392647 7 similar to mKIAA0038 protein LOC392879 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 HOXA4 7p15.3 homeo box A4 HOXA5 7p15.3 homeo box A5 HOXA6 7p15.3 homeo box A6 LOC392880 7 similar to hypothetical protein MGC2574 HOXA7 7p15.3 homeo box A7 HOXA9 7p15.3 homeo box A9 HOXA10 7p15.3 homeo box A10 HIBADH 7p15.2 3-hydroxyisobutyrate dehydrogenase HOXA11 7p15.3 homeo box A11 HOXA11S 7p15.2 homeo box A11, antisense HOXA13 7p15.3 homeo box A13 EVX1 7p15-p14 eve, even-skipped homeo box homolog 1 (Drosophila) LOC392008 7 similar to 60S ribosomal protein L35 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2653 - 313 - 2009 19727442
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
    Reproductivefemale systemuteruscervix predominantly
     female systemplacenta  highly
     male systemprostate  highly
    Respiratorylung    
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral highly
    Epithelialbarrier/liningendometrium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, expressed in the embryonic paramesonephric (Müllerian) ducts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an homeobox DNA binding domain
  • helix-turn-helix
  • HOMOLOGY
    interspecies homolog to murine Hoxa11 (98.1 pc)
    homolog to zebrafish hoxa11b (76 pc)
    Homologene
    FAMILY
  • ABD-B homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of uterine development
  • required for female fertility
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • essential for organogenesis of the uterosacral ligaments
  • required for prolactin expression in decidualized endometrial stromal cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • physical association of HOXA11 and FOXO1, and binding of both factors to an enhancer region of the decidual prolactin promoter
  • cell & other
    REGULATION
    inhibited by YY1 via direct physical interaction
    Other spatially and temporally regulated during embryonic development
    ASSOCIATED DISORDERS
    corresponding disease(s) RUSAT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with NUP98 in t(7;11) (p15;p15) in chronic myeloid leukemia (in acute leukemia phase)
    constitutional     --low  
    with both collagens (collagen type I, collagen type III) was dramatically decreased in women with pelvic organ prolapse
    tumoral     --other  
    its DNA methylation was independently associated with poor outcome in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS