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FLASH GENE
Symbol HOXA11 contributors: mct - updated : 02-02-2011
HGNC name homeobox A11
HGNC id 5101
Corresponding disease
RUSAT radio-ulnar synostosis with amegakaryocytic thrombocytopenia
Location 7p15.2      Physical location : 27.220.776 - 27.224.835
Synonym name homeo box A11 (1I)
Synonym symbol(s) HOX1I, HOX1, RSAT
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • homeobox gene A cluster
    • STRUCTURE 4.06 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    text structure polyalamine stretch in exon 1
    MAPPING cloned Y linked N status confirmed
    Map see HOXA@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2653 - 313 - 2009 19727442
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
    Reproductivefemale systemuteruscervix predominantly
     female systemplacenta  highly
     male systemprostate  highly
    Respiratorylung    
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral highly
    Epithelialbarrier/liningendometrium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, expressed in the embryonic paramesonephric (Müllerian) ducts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an homeobox DNA binding domain
  • helix-turn-helix
    • HOMOLOGY
    interspecies homolog to murine Hoxa11 (98.1 pc)
    homolog to zebrafish hoxa11b (76 pc)
    Homologene
    FAMILY
  • ABD-B homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of uterine development
  • required for female fertility
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • essential for organogenesis of the uterosacral ligaments
  • required for prolactin expression in decidualized endometrial stromal cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • physical association of HOXA11 and FOXO1, and binding of both factors to an enhancer region of the decidual prolactin promoter
    • cell & other
    REGULATION
    inhibited by YY1 via direct physical interaction
    Other spatially and temporally regulated during embryonic development
    ASSOCIATED DISORDERS
    corresponding disease(s) RUSAT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with NUP98 in t(7;11) (p15;p15) in chronic myeloid leukemia (in acute leukemia phase)
    constitutional     --low  
    with both collagens (collagen type I, collagen type III) was dramatically decreased in women with pelvic organ prolapse
    tumoral     --other  
    its DNA methylation was independently associated with poor outcome in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS