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FLASH GENE
Symbol HOOK2 contributors: mct - updated : 22-12-2011
HGNC name hook homolog 2 (Drosophila)
HGNC id 19885
Location 19p13.2      Physical location : 12.873.816 - 12.886.434
Synonym name hook2 protein
Synonym symbol(s) HK2, hHK2
DNA
TYPE functioning gene
STRUCTURE 12.62 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF442 19p13.13 zinc finger protein 442 LOC388510 19 LOC388510 LOC90576 19p13.2 hypothetical protein LOC90576 ZNF443 19p13.13 zinc finger protein 443 FLJ38281 19p13.2 hypothetical protein FLJ38281 MGC26914 19p13.2 hypothetical protein MGC26914 PGK1P2 6p21-p12 phosphoglycerate kinase 1, pseudogene 2 ZNF490 19p13.2 zinc finger protein 490 FLJ90396 19p13.2 hypothetical protein FLJ90396 MGC4238 19p13.2 hypothetical protein MGC4238 LOC284393 19p13.2 similar to 60S ribosomal protein L10 (QM protein homolog) MAN2B1 19p13.2-p13.1 mannosidase, alpha, class 2B, member 1 PTD008 19p13.2 PTD008 protein DHPS 19p13.12-p13.11 deoxyhypusine synthase MGC10870 19p13.2 hypothetical protein MGC10870 TNPO2 19p13.2 transportin 2 (importin 3, karyopherin beta 2b) MGC2803 19p13.2 hypothetical protein MGC2803 ASNA1 19q13.3 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) VMD2L1 19p13.2-p13.12 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) HOOK2 19p13.2 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) RNASEH2A 19p13.2 ribonuclease H2, large subunit JUNB 19p13.2 jun B proto-oncogene PRDX2 13q12 peroxiredoxin 2 RTBDN 19p12 retbindin DNASE2 19p13.2 deoxyribonuclease II, lysosomal KLF1 19p13.13-p13.12 Kruppel-like factor 1 (erythroid) GCDH 19p13.2 glutaryl-Coenzyme A dehydrogenase FARSLA 19p13.2 phenylalanine-tRNA synthetase-like, alpha subunit CALR 19p13.3-p13.2 calreticulin RAD23A 19p13.2 RAD23 homolog A (S. cerevisiae) PLINP-1 19p13.2 papillomavirus L2 interacting nuclear protein 1 FLJ38607 19p13.2 hypothetical protein FLJ38607 LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor) LYL1 19p13.2-p13.1 lymphoblastic leukemia derived sequence 1 FLJ20244 19p13.13 hypothetical protein FLJ20244 BTBD14B 19p13.13 BTB (POZ) domain containing 14B
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 2622 - 717 - 2007 17140400
23 - 2628 - 719 - 2007 17140400
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrainhindbrainmedulla oblongata  
 braindiencephalonamygdala  
Respiratorylung    
 respiratory tractlarynx   
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain directly binds to centriolin/CEP110
  • HOMOLOGY
    intraspecies homolog to HOOK1 and HOOK3
    Homologene
    FAMILY hook family
    CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localizes to the centrosome through all phases of the cell cycle
  • in retinal epithelial cells, localizes at the Golgi apparatus and centrosome/basal body, a strategic partitioning for ciliogenesis
  • basic FUNCTION
  • required for endocytic trafficking
  • required for protein transport from the ER to the golgi complex
  • potentially contributes to the establishment and maintenance of centrosomal structure and function
  • contributes to the establishment and maintenance of the pericentrosomal localization of aggresomes by promoting the microtubule-based delivery of protein aggregates to pericentriolar aggresomes
  • linker protein that is essential for regulation of the micotubules network at the centrosome, as a binding partner of CENPF
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZC3H14 binds to HOOK2, a protein previously implicated in aggresome formation
  • binding partner of CENPF
  • interacts with PCM1 in a complex that also contains RAB8A and regulates a limiting step required for further initiation of ciliogenesis after centriole maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS