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FLASH GENE
Symbol HOOK1 contributors: mct - updated : 31-03-2015
HGNC name hook homolog 1 (Drosophila)
HGNC id 19884
Location 1p32.1      Physical location : 60.280.532 - 60.342.049
Synonym name micotubule-binding HOOK1
Synonym symbol(s) HK1, MGC10642
DNA
TYPE functioning gene
STRUCTURE 61.52 kb     22 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC127406 1p32.2 similar to 33K laminin receptor homolog - bovine PPAP2B 1pter-p22.1 phosphatidic acid phosphatase type 2B PRKAA2 1p31 protein kinase, AMP-activated, alpha 2 catalytic subunit LOC199920 1p32.2 hypothetical protein LOC199920 C8A 1p32 complement component 8, alpha polypeptide C8B 1p32 complement component 8, beta polypeptide DAB1 1p32-p31 disabled homolog 1 (Drosophila) MPRP-1 1p32.1 metalloprotease related protein 1 TACSTD2 1p32-p31 tumor-associated calcium signal transducer 2 AK2B 1p32.1 adenylate kinase 2 pseudogene KIAA1915 1p32.1 KIAA1915 protein JUN 1p32-p31 v-jun sarcoma virus 17 oncogene homolog (avian) LOC391044 1 similar to prohibitin FLJ10986 1p32.1 hypothetical protein FLJ10986 HOOK1 1p32.1 hook homolog 1 (Drosophila) CYP2J2 1p31.3-p31.2 cytochrome P450, family 2, subfamily J, polypeptide 2 MGC34837 1p32.1 hypothetical protein MGC34837 NFIA 1p31.3-p31.2 nuclear factor I/A BBP 1p32.1 beta-amyloid binding protein precursor INADL 1p32.1-p31.3 beta-amyloid binding protein precursor FLJ10884 1p32.1 hypothetical protein FLJ10884 LOC388637 1 similar to LOC163782 protein USP1 1p32.1-p31.3 ubiquitin specific protease 1 ANGPTL3 1p31 angiopoietin-like 3 AUTL1 1p31.3 AUT-like 1, cysteine endopeptidase (S. cerevisiae) LOC199897 1p32.1 hypothetical LOC199897 LOC388638 1 LOC388638 FOXD3 1p32-p31 forkhead box D3 ALG6 1p31.3 forkhead box D3 ITGB3BP 1p31.3 integrin beta 3 binding protein (beta3-endonexin) KIAA1799 1p31.3 KIAA1799 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 5865 84.5 728 - 1999 9927460
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Reproductivefemale systemuteruscervix moderately
 male systemtestis  highly
Urinarykidney    
Visualeyeanterior segmentcornea  
 eyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal domain,
  • a large and central coiled-coil domain mediating the homodimerization
  • a C-terminal domain
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Hook1 (92.7 pc)
    homolog to murine Hook1 (92.6 pc)
    intraspecies homolog to HOOK2 and HOOK3
    Homologene
    FAMILY
  • hook family
  • vdp/uso1/ybl047c family
  • CATEGORY regulatory , structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • required for protein transport from the ER to the golgi complex
  • involved in tethering membrane bound organelles to the cytoskeleton
  • required for spermatid differentiation
  • probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton
  • microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into RAB22A-dependent tubules associated with recycling
  • role for HOOK1 as an endosomal cargo adaptor that routes Clathrin-independent endocytosis (CIE) cargo to the recycling endosomes
  • HOOK1, microtubules, and RAB22A work in coordination to directly recycle the cargo and facilitate cell spreading
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • spermatogenesis
  • microtubule cytoskeleton organization
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CLN3
  • interacting with microtubules
  • interacting with VPS18
  • HOOK1 was an endogenous negative regulator of PTPN11 phosphatase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS