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FLASH GENE
Symbol HOMEZ contributors: mct/npt - updated : 28-01-2009
HGNC name homeobox and leucine zipper encoding
HGNC id 20164
Location 14q11.2      Physical location : 23.742.843 - 23.755.309
Synonym name
  • homeodomain leucine zipper-containing factor
  • KIAA1443
  • Synonym symbol(s) KIAA1443
    DNA
    TYPE functioning gene
    STRUCTURE 12.39 kb     2 Exon(s)
    motif repetitive sequence   ALU
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text multiple alternatively spliced variants encoding two distinct isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3741 - 550 - Beausoleil (2004)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three atypical homeodomains
  • two leucine zipper-like motifs
  • a putative nuclear localization signal
  • an acidic domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Homez
    Homologene
    FAMILY
  • ZHX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as a transcriptional regulator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with HOXC8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS