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FLASH GENE
Symbol HOMER3 contributors: KTN/npt - updated : 29-08-2007
HGNC name homer homolog 3 (Drosophila)
HGNC id 17514
Location 19p13.11      Physical location : 19.040.009 - 19.052.041
Synonym name homer, neuronal immediate early gene 3
Synonym symbol(s) HOMER-3
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
MAPA 19p13.11 monocyte and plasmacytoid activated molecule SSBP4 19p13.1 single stranded DNA binding protein 4 ISYNA1 19p13.11 myo-inositol 1-phosphate synthase A1 DKFZp434I1916 ELL 19p13.1 elongation factor RNA polymerase II FKBP8 19p12 FK506 binding protein 8, 38kDa MGC2749 19p13.11 hypothetical protein MGC2749 UBA52 19p13.1-p12 ubiquitin A-52 residue ribosomal protein fusion product 1 FLJ20850 19p13.11 hypothetical protein FLJ20850 CRLF1 19p12 cytokine receptor-like factor 1 C19orf4 19p12 chromosome 19 open reading frame 4 FLJ11078 19p13.11 hypothetical protein FLJ11078 MECT1 19p13 mucoepidermoid carcinoma translocated 1 COMP 19p13.1 cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) RENT1 19p13.2-p13.11 regulator of nonsense transcripts 1 GDF1 19p13.1-p12 growth differentiation factor 1 LASS1-GDF1 19p12 LAG1 longevity assurance homolog 1 (S. cerevisiae), growth differentiation factor 1 transcription unit LASS1 19p13.1-p12 LAG1 longevity assurance homolog 1 (S. cerevisiae) LOC388518 19 LOC388518 COPE 19p13.1 coatomer protein complex, subunit epsilon DDX49 19p12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 HOMER3 19p13.11 homer homolog 3 (Drosophila) SFRS14 19p12-p11 splicing factor, arginine/serine-rich 14 MGC19595 19p13.11 hypothetical gene MGC19595 MGC26694 19p13.11 hypothetical protein MGC26694 FLJ20422 19p13.11 hypothetical protein FLJ20422 MEF2B 19p12 MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) RFXANK 19p12 regulatory factor X-associated ankyrin-containing protein TRA16 19p13.11 TR4 orphan receptor associated protein TRA16 CSPG3 19p12 chondroitin sulfate proteoglycan 3 (neurocan) TM6SF2 19p13.3-p12 transmembrane 6 superfamily member 2 SF4 19p13 splicing factor 4 KIAA0892 19p13.11 KIAA0892 p66alpha 19p13.11 p66 alpha
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  lowly
 liver   highly
Lymphoid/Immunethymus   lowly
Nervousbrain   lowly
 braindiencephalonhypothalamus  
 brainhindbraincerebellum  
Reproductivefemale systemuteruscervix moderately
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PDZ (PSD95/disc large/ZO-1) domains
  • a WAS homology domain (WH1)
  • a variant EVASP and a C terminal coiled-coil region
  • mediating self-multimerization
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to chimpanzee HOMER3 (99.45 pc)
    homolog to rattus Homer3 (91.06 pc)
    homolog to murine Homer3 (90.17 pc)
    homolog to chicken HOMER3 (72.29 pc)
    Homologene
    FAMILY
  • Homer family of cytoplasmic scaffolding proteins
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text postsynaptic density
    basic FUNCTION
  • clustering and linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs signaling
  • being a negative regulator of T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOMER1
  • FAT
  • interacting with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS