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FLASH GENE
Symbol HOGA1 contributors: mct - updated : 24-03-2013
HGNC name 4-hydroxy-2-oxoglutarate aldolase 1
HGNC id 25155
Corresponding disease
PHXL3 hyperoxaluria, primary, type III
Location 10q24.2      Physical location : -
Synonym name
  • dihydrodipicolinate synthase-like, mitochondrial
  • DHDPS-like protein
  • hypothetical protein LOC112817
  • chromosome 10 open reading frame 65
  • dihydrodipicolinate synthetase homolog 2 (E. coli)
  • N-acetylneuraminate pyruvate lyase 2 (putative)
  • DHDPS-like protein
  • protein 569272
  • dihydrodipicolinate synthase-like, mitochondrial
    • Synonym symbol(s) FLJ37472, C10orf65, DHDPS2, NPL2, C10orf65, DHDPS2, DHDPSL, HP3, NPL2
    EC.number 4.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 28.70 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2501 35.2 327 - 2004 15164054
    3 - 2012 - 164 - 2004 15164054
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • DHDPS family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • encoding 4-hydroxy-2-oxoglutarate aldolase, catalyzing the final step in the metabolic pathway of hydroxyproline
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHXL3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS