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FLASH GENE
Symbol HNRNPUL1 contributors: mct/npt - updated : 22-04-2009
HGNC name heterogeneous nuclear ribonucleoprotein U-like 1
HGNC id 17011
Location 19q13.2      Physical location : 41.768.390 - 41.813.810
Synonym name
  • E1B-55kDa-associated protein 5
  • adenovirus early region 1B-associated protein 5
  • Synonym symbol(s) E1BAP5, FLJ12944, HNRPUL1, E1B-AP5, FLJ12944
    DNA
    TYPE functioning gene
    STRUCTURE 43.69 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4201 - 856 - Kzhyshkowska, Olsen (2006)
    - - 3716 - 804 - Kzhyshkowska, Olsen (2006)
    - - 1800 - 122 - Kzhyshkowska, Olsen (2006)
    15 - 3714 - 756 - Kzhyshkowska, Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • heterogeneous nuclear ribonucleoprotein (hnRNP) family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play an important role in nucleocytoplasmic RNA transport
  • playing a role as a key regulator of ATR signaling pathways activated during Adenovirus infection (Blackford 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • binds specifically to adenovirus E1B-55kDa oncoprotein
  • targeted by adenovirus (Ad) E1B-55K during infection (Blackford 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to early-onset myocardial infarction (MI)
    Variant & Polymorphism SNP associated with early-onset MI (Shiffman 2006)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS