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FLASH GENE
Symbol HNRNPR contributors: mct - updated : 19-06-2019
HGNC name heterogeneous nuclear ribonucleoprotein R
HGNC id 5047
Corresponding disease
MRBSG mental retardation with brain, skeletal and genital anomalies
Location 1p36.11      Physical location : 23.636.276 - 23.670.853
Synonym symbol(s) HNRPR, FLJ25714
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2585 - 532 - -
- - 2760 - 636 - -
- - 2589 - 535 - -
- - 2751 70 633 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cordposterior horn   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three repeats of quasi-RRM domains that bind to RNAs
  • an acidic approximately 150-residue N terminus
  • a C-terminal nuclear localization signal
  • an octapeptide (PPPRMPPP) resembling the B cell epitope of snRNP core protein B
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing an important role in processing of precursor mRNA in the nucleus
  • essential role for HNRNPR in human development
  • is required to maintain the tight regulation of these genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding through its arg-gly-gly-rich RNA recognition motif domains.
    small molecule
    protein
  • interacting with SMN proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRBSG
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS