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FLASH GENE

Symbol

HNRNPM

contributors: npt/mct - updated : 31-08-2018

HGNC name	heterogeneous nuclear ribonucleoprotein M
HGNC id	5046

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 8.509.802 - 8.553.994
Synonym name	heterogeneous nuclear RNA ribonucleoprotein complex, core protein M, recognized by monoclonal antibody 6D12
	M4 protein
	N-acetylglucosamine receptor 1
	Carcinoembryonic antigen receptor 4
Synonym symbol(s)	HTGR1, NAGR1, HNRPM4, DKFZp547H118, CEAR4, HNRPM, HNRPM4, hnRNP M,

DNA

TYPE	functioning gene
STRUCTURE	44.54 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	with four isoforms M1, M2, M3, M4 (64,68kDa) (Datar)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005968 16 - 2553 NP_005959 77.4 730 - 1996 8692693 NM_031203 17 - 2436 NP_112480 73.5 691 - 1996 8692693 variant 1 - - - isoform 1 68 - - Datar (1993) also called M1 variant 2 - - - isoform 2 68 - - Datar (1993) also called M2 NM_001297418 14 - 2540 NP_001284347 68 595 - Datar (1993) also called M3 variant 4 - - 2450 isoform 4 77 729 - 1996 8692693 also called M4

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   pharynx       highly Endocrine thyroid       highly Gustatory (taste) tongue         Lymphoid/Immune thymus         Reproductive female system uterus     highly   male system testis       Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three RNP-CS domains
	A central region spanning amino acids 248–344 required for interaction with CDC5L/PLRG1

conjugated

RiboP

HOMOLOGY

Homologene

FAMILY

HNRP family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in splicing
	N-acetyl-glucosamine-specific receptor
	is able to associate with early spliceosomes and to influence splicing patterns of specific pre-mRNAs
	abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex
	involvement in the spliceosome machinery through its interaction with the CDC5L/PLRG1 spliceosomal subcomplex
	can influence both constitutive and alternative splicing
	participation of HNRNPM in an expanding network of protein-protein interactions suggesting its important functioning in the coordination of transcriptional and post-transcriptional events
	promotes breast cancer metastasis by activating the switch of alternative splicing that occurs during epithelial-mesenchymal transition (EMT)
	ESRP1 and HNRNPM are splicing regulators that promote an epithelial splicing program and a mesenchymal splicing program, respectively

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of heterogeneous nuclear RNA ribonucleoprotein complex

INTERACTION

DNA

RNA

binding

small molecule

protein	carcinoembryonic antigen binds to Kupffer cells and macrophages to a membrane-anchored homolog of HNRPM (CEAR)
	HNRNPM interacts with SFPQ and NONO and co-localizes within defined nuclear structures
	interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1)
	NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
	nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
	HNRNPM promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF2
	CD44 is a key downstream target of HNRNPM
	cooperative function of HNRNPM and NONO as regulators of internal ribosome entry site (IRES)-dependent translation, indicating the involvement of a promoter-dependent mechanism
	complex modes of interaction between HNRNPM and ESRP1 in regulation of splicing in disease-relevant contexts

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS