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FLASH GENE
Symbol HNRNPM contributors: npt/mct - updated : 31-08-2016
HGNC name heterogeneous nuclear ribonucleoprotein M
HGNC id 5046
Location 19p13.2      Physical location : 8.509.802 - 8.553.994
Synonym name
  • heterogeneous nuclear RNA ribonucleoprotein complex, core protein M, recognized by monoclonal antibody 6D12
  • M4 protein
  • N-acetylglucosamine receptor 1
  • Carcinoembryonic antigen receptor 4
  • Synonym symbol(s) HTGR1, NAGR1, HNRPM4, DKFZp547H118, CEAR4, HNRPM, HNRPM4, hnRNP M,
    DNA
    TYPE functioning gene
    STRUCTURE 44.54 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text with four isoforms M1, M2, M3, M4 (64,68kDa) (Datar)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2553 77.4 730 - 1996 8692693
    17 - 2436 73.5 691 - 1996 8692693
    - - - 68 - - Datar (1993)
    also called M1
    - - - 68 - - Datar (1993)
    also called M2
    14 - 2540 68 595 - Datar (1993)
    also called M3
    - - 2450 77 729 - 1996 8692693
    also called M4
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     pharynx   highly
    Endocrinethyroid   highly
    Gustatory (taste)tongue    
    Lymphoid/Immunethymus    
    Reproductivefemale systemuterus  highly
     male systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three RNP-CS domains
  • A central region spanning amino acids 248344 required for interaction with CDC5L/PLRG1
  • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • HNRP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in splicing
  • N-acetyl-glucosamine-specific receptor
  • is able to associate with early spliceosomes and to influence splicing patterns of specific pre-mRNAs
  • abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex
  • involvement in the spliceosome machinery through its interaction with the CDC5L/PLRG1 spliceosomal subcomplex
  • can influence both constitutive and alternative splicing
  • participation of HNRNPM in an expanding network of protein-protein interactions suggesting its important functioning in the coordination of transcriptional and post-transcriptional events
  • promotes breast cancer metastasis by activating the switch of alternative splicing that occurs during epithelial-mesenchymal transition (EMT)
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • carcinoembryonic antigen binds to Kupffer cells and macrophages to a membrane-anchored homolog of HNRPM (CEAR)
  • HNRNPM interacts with SFPQ and NONO and co-localizes within defined nuclear structures
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1)
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • HNRNPM promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF2
  • CD44 is a key downstream target of HNRNPM
  • cooperative function of HNRNPM and NONO as regulators of internal ribosome entry site (IRES)-dependent translation, indicating the involvement of a promoter-dependent mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS