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FLASH GENE
Symbol HNRNPD contributors: mct/ - updated : 04-06-2014
HGNC name heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HGNC id 5036
Location 4q21.22      Physical location : 83.274.466 - 83.295.149
Synonym name
  • AU-rich element RNA-binding protein 1
  • ARE-binding protein AUFI, type A
  • Synonym symbol(s) AUF1, P37, ROD, HNRPD, HNRPND, AUF1A
    DNA
    TYPE functioning gene
    STRUCTURE 20.68 kb     9 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text four isoforms that result from alternative splicing of exons 2 and 7 from a common pre-mRNA (PMID: 20926381)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2053 - 287 - 2007 17603996
    also called p37 or isoform d
    8 splicing 2110 - 306 - 2008 18844578
  • also called p40, isoform c
  • p40 isoform selectively plays a critical, positive role in IL10 expression upon LPS (ndotoxin/lipopolysaccharide) exposure
  • 8 splicing 2200 - 336 - 2007 17603996
    also called p42, isoform b
    9 splicing 2257 - 355 - 2007 17603996
    also called p45, isoform a
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessels    
    Endocrineadrenal gland   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularsmooth   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two non identical RNA recognition motifs (RRM) and
  • a C terminal glycine-rich Q domain (p37), a 19AA N terminal insert in p30, p45 and C terminal insert in p42 and p45, C-terminus of AUF1 containing arginine-glycine-glycine (RGG) repeat motifs that are dimethylated
  • conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Hnrpd
    intraspecies homolog to HNRPDL
    Homologene
    FAMILY
  • HNRP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • potential mediator of (AU rich element) found within the 3'utr of many protooncogene and cytokine messengers, mediating their fast degradation
  • modulating the AT1 receptor expression
  • involved in the ARE/AUBP-mediated modulation of BCL2 mRNA decay during apoptosis
  • controlling proliferation with TIAL1 by a MYC-dependent pathway
  • expressed in the developing brain, binds to AT-rich double-stranded DNA, and regulates enkephalin gene expression
  • rapamycin-responsive binding protein to the 5prime-terminal oligopyrimidine element of mRNAs
  • TOP (5prime-terminal oligopyrimidine) mRNA-binding protein that may participate in the translational suppression of TOP mRNAs resulting from rapamycin treatment
  • may be involved in thyroid carcinoma progression
  • important in the maintenance of splenic follicular B cells and adequate humoral immune responses
  • regulates a critical node within the NFKB signaling pathway to permit IL10 induction for the anti-inflammatory arm of an innate immune response
  • AU-rich element (ARE)-binding protein that recruits translation initiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction
  • links maintenance of telomere length and normal aging to attenuation of inflammatory cytokine expression and inhibition of cellular senescence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA catabolism
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • complexing with heat shock protein Hsp70, translation initiation factor EIF4G and poly (A) binding protein (PABPx)
  • stabilization of PTH (parathormone) transcript
  • target of MYC proto-oncogene mRNA
  • interacting with SFN
  • polyamines modulate the stability of JUND mRNA in intestinal epithelial cells through ELAVL1 and HNRNPD
  • HSPB2 modulates HNRNPD proteolysis and AU-rich element-mediated mRNA degradation
  • CDKN2A is a modulator of transcription and apoptosis through controlling the expression of two major transcription regulators, HNRNPD and E2F1
  • binds to many ARE-mRNAs and assembles other factors necessary to recruit the mRNA degradation machinery
  • ZFP36 could bind to certain isoforms of another AU-rich element-binding protein, HNRNPD, as well as a related protein, laAUF
  • regulates VEGFA expression, and it is an RGG peptide that suppresses VEGFA gene expression
  • under hypoxic conditions VHL is downregulated, whereas HNRNPD and ELAVL1 binding to VEGFA mRNA is maintained, and this complex is associated with stabilized mRNA
  • CDKN2A stabilizes the CDKN1A mRNA through negative regulation of the mRNA decay-promoting HNRNPD protein
  • HNRNPD is a negative regulator of FST expression and participates in the regulation of cell survival under glucose deprivation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be considered as a new, additional marker for thyroid carcinoma
  • Therapy target
    ANIMAL & CELL MODELS
  • Auf1-deficient mice undergo striking telomere erosion, markedly increased DNA damage responses at telomere ends, pronounced cellular senescence, and rapid premature aging