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FLASH GENE
Symbol HNRNPC contributors: mct/shn - updated : 05-01-2011
HGNC name heterogeneous nuclear ribonucleoprotein C (C1/C2)
HGNC id 5035
Location 14q11.2      Physical location : 21.677.297 - 21.737.638
Synonym name
  • heterogeneous nuclear ribonucleoproteins C1/C2
  • hnRNP C1/C2
  • nuclear ribonucleoprotein particle C1 protein
  • nuclear ribonucleoprotein particle C2 protein
  • Synonym symbol(s) C1, C2, HNRP, SNRPC, HNRPC, MGC104306, MGC105117, MGC117353, MGC131677
    DNA
    TYPE functioning gene
    STRUCTURE 60.34 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map en - D14S1023 - D14S1070 - HNRNPC - D14S1003 - D14S50 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 3252 - 306 - -
    8 splicing 3213 - 293 - -
    8 splicing 3187 - 293 - -
    8 splicing 3226 - 306 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrineneuroendocrinepituitary  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RRM domain (RNA recognition motif)
  • two consensus sequence-type RNA domains
  • a glycine-rich auxiliary domain
  • secondary structure beta alpha beta beta alpha beta; four-stranded antiparallel beta-sheet, two alpha helices and relatively unstructured N and C terminal regions
    conjugated RiboP , PhosphoP
    HOMOLOGY
    interspecies ortholog to Hnrnpc, Mus musculus
    ortholog to HNRNPC, pan troglodytes
    ortholog to Hnrnpc, rattus norvegicus
    Homologene
    FAMILY
  • heterogeneous nuclear ribonucleoprotein family
  • RALY subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nucleus at interphase, cytoplasm at the G2/M phase
    basic FUNCTION
  • influencing pre-mRNA processing and other aspects of mRNA metabolism and transport
  • playing a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core HNRNP
  • can act as a tetramer and is involved in the assembly of 40S hnRNP particles
  • playing a role with CSDE1 in internal initiation of translation during mitosis
  • may be a key determinant of the temporal patterns of vitamin D-resistant rickets occupancy
  • role in splicing regulation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the hnRNP core complex
  • component of the ribonucleosome
  • with MBD1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region
  • INTERACTION
    DNA 3' end of the RNA representing the negative strand of the HCV genome
    RNA binding to pre-mRNA
    small molecule
    protein
  • Grb2 and Grb3-3
  • protein-protein interaction of RALY with EIF4A3, FMR1, and HNRNPC
  • cell & other
    REGULATION
    Other phosphorylated in response to physiologic levels of hydrogen peroxide in endothelial cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in hereditary vitamin D-resistant rickets resulting in hormone resistance
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS