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FLASH GENE
Symbol HNRNPAB contributors: mct - updated : 05-01-2011
HGNC name heterogeneous nuclear ribonucleoprotein A/B
HGNC id 5034
Location 5q35.3      Physical location : 177.631.507 - 177.638.183
Synonym name
  • apobec-1 binding protein 1
  • heterogeneous nuclear ribonucleoprotein C
  • AU-rich element RNA-binding protein 2
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1
  • hnRNP type A/B protein
    • Synonym symbol(s) ABBP1, CBF-A, AUF2, HNRPAB, FLJ40338
    DNA
    TYPE functioning gene
    STRUCTURE 6.68 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1837 - 332 ubiquitous 1991 1717314
    7 splicing 1696 30.6 285 ubiquitous 1991 1717314
  • lacking 141 bases in the coding region compared to variant 1
  • maintaining the same reading frame
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two RNA binding domains each containing one RNP1 and one RNP2 sequences
  • eight glycin stretch domains,glycin rich domain with nine Gly-Tyr repeats (only in isoform a)
  • ATP/GTP binding fold
    • conjugated RiboP , PhosphoP , Other
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Hnrpab
    homolog to rattus Hnrpab
    Homologene
    FAMILY
  • heterogeneous nuclear ribonucleoprotein family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mRNA editing (for example apolipoprotein B mRNA)
  • play a role in RNA processing/trafficking, telomere maintenance, and transcriptional regulation
  • potentially regulates osteopontin transcription in endotoxin-stimulated macrophages
    • CELLULAR PROCESS nucleotide, RNA splicing
    protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • ATP/GTP
    • protein
  • binding to p63a
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS