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FLASH GENE
Symbol HMX3 contributors: mct/npt - updated : 11-04-2008
HGNC name H6 family homeobox 3
HGNC id 5019
Location 10q26.13      Physical location : 124.895.566 - 124.897.246
Synonym name
  • homeobox (H6 family) 3
  • homeobox protein HMX3
  • homeobox protein Nkx-5.1
    • Synonym symbol(s) NKX5-1
    DNA
    TYPE functioning gene
    STRUCTURE 1.68 kb     2 Exon(s)
    MAPPING cloned N linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1074 - 357 - Miller (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Reproductivefemale systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in the craniofacial region of developing embryos
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • HMX homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be functioning redundantly to control embryonic development of the central nervous system
  • have a role in sensorineural hearing (Miller 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for human inner ear vestibular development and a role in sensorineural hearing observed in del 10q26 patients (Miller 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hmx2/hmx3 knockout mice have vestibular anomalies