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Symbol HMMR contributors: mct/ - updated : 09-10-2013
HGNC name hyaluronan-mediated motility receptor (RHAMM)
HGNC id 5012
Location 5q34      Physical location : 162.887.516 - 162.918.949
Synonym name
  • intracellular hyaluronic acid binding protein
  • receptor for hyaluronan-mediated motility
  • CD168 antigen
  • Synonym symbol(s) RHAMM, IHABP, CD168, MGC119494, MGC119495
    TYPE functioning gene
    STRUCTURE 31.43 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure cell cycle-dependent synthesis is controlled by its promoter on the transcriptional level
    MAPPING cloned Y linked   status provisional
    Map cen - D5S422 - HMMR - D5S621 /D5S423 - qter
    Physical map
    LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor FLJ31951 5q33.3 hypothetical protein FLJ31951 MGC10067 5q33.3 hypothetical protein MGC10067 IL12B 5q31.1-q33.1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ADRA1B 5q33.1 adrenergic, alpha-1B-, receptor TTC1 5q32-q33.2 tetratricopeptide repeat domain 1 KIAA1935 5q34 KIAA1935 protein FABP6 5q23-q35 fatty acid binding protein 6, ileal (gastrotropin) FLJ14166 5q34 hypothetical protein FLJ14166 C1QTNF2 5q33.3 C1q and tumor necrosis factor related protein 2 LOC63920 5q34 transposon-derived Buster3 transposase-like SLU7 5q34 step II splicing factor SLU7 PTTG1 5q35.1 pituitary tumor-transforming 1 FLJ21477 5q34 hypothetical protein FLJ21477 GABRB2 5q33.1-q34 gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRA6 5q33.1-q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GABRA1 5q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GABRG2 5q31.3-q33.2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 MRP63P6 5q34 mitochondrial ribosomal protein 63 pseudogene 6 CCNG1 5q32-q34 cyclin G1 LOC134492 5q34 similar to RIKEN cDNA 2700047N05 HMMR 5q33.3 hyaluronan-mediated motility receptor (RHAMM) MAT2B 5q34-q35.1 methionine adenosyltransferase II, beta LOC391844 5 similar to beta-tropomyosin LOC391845 5 similar to ribosomal protein S15 LOC391846 5 similar to 60S ribosomal protein L7 LOC134541 5q35.1 similar to Ten-m2 ODZ2 5q35.1 odd Oz/ten-m homolog 2 KIBRA 5q35.1 KIBRA protein RARS 5pter-q11 arginyl-tRNA synthetase
    TRANSCRIPTS type messenger
    text five isoforms (58, 60, 64, 70, 84kDa) (Spicer)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3141 - 724 - 1996 8890751
    18 splicing 3144 - 725 - 1996 8890751
    15 - 2917 - 638 - 1996 8890751
    17 - 3096 - 709 - 1996 8890751
       expressed in (based on citations)
    cell lineage
    cell lines breast cancer cells
    at STAGE
  • an acidic coiled coil domain
  • N-terminal motif overlapping the defined hyaluronan binding domain
  • two microtubule-binding regions
  • C-terminal 728LKDENSQLKSEVSKL742 microtubule-binding site
    interspecies homolog to C.elegans c14h10.2
  • ACC family
  • CATEGORY adhesion , protooncogene , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
  • the N-terminus interacts with microtubules and a separate carboxy-terminal domain is required for centrosomal targeting
  • associated with the cytoskeleton, microtubules, centrosomes and the mitotic spindle
  • found in the cell nucleus, on interphase microtubules, mitotic spindles, centrosomes, and within mitochondria
  • distributed in both the cytoplasm and nucleus
  • localized to the microtubule cytoskeleton and along mitotic spindles
  • basic FUNCTION
  • cell surface receptor for hyaluronan, and a microtubule-associated intracellular hyaluronan binding protein involved in signal transduction via Src tyrosine kinase family
  • functioning in the maintenance of spindle integrity
  • playing an important role in maintenance of embryonic stem cells pluripotency, viability, and cell cycle control
  • playing a role already in S phase
  • oncogenic protein implicated in the progression of many cancers, including breast, acute myeloid leukemia, multiple myeloma, gastric, and prostate cancers
  • required for regulating stability of interphase and mitotic microtubules and this function resided in the C-terminal 728LKDENSQLKSEVSKL742 microtubule-binding site
  • control the structure of interphase and mitotic spindle microtubules and these effects are driven by MEK1/ERK1/2 kinase activity
  • has a predominant role in the cell cycle in immortalized cells (HCF)
  • ARPC5 and HMMR, in addition to PRKCA, were required for migration of neointimal smooth muscle cells
  • centrosomal protein that contributes to the stability of the mitotic spindle
  • may play a key role in the osteoblastic differentiation process
  • ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis
  • cell-surface receptor for hyaluronan that regulates embryonic stem cell pluripotency and differentiation
  • required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
  • CELLULAR PROCESS cell cycle
    cell communication
    signaling signal transduction
    a component
  • subunit of the HARC complex
    small molecule
  • hayluronic acid
  • a direct interaction with microtubules and an association with dynein
  • interacting with CD44 (HMMR and CD44 act together in a hyaluronan-dependent autocrine mechanism to coordinate sustained signaling through ERK1,2, leading to high basal motility of invasive breast cancer cells)
  • interacts with the spindle assembly factors dynein and TPX2 (like TPX2, its expression is up-regulated during mitosis)
  • associates with both interphase and mitotic spindle microtubules by directly binding to alpha- and beta-tubulin through a highly conserved leucine zipper in its C- terminus
  • MTA1 transcriptionally stimulates expression of the hyaluronan-mediated motility receptor (HMMR) and consequently regulates cancer invasion and migratory function
  • DYNLL1 interacted with a spindle-microtubule-associated adaptor formed by FAM83D and HMMR via TQT motifs in FAM83D)
  • cell & other
    repressed by TP53
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlate with the malignant condition and might be linked to the increased or abnormal cell proliferation in human oral squamous cell carcinomas
    tumoral     --over  
    in breast cancer is predictive of poor clinical outcome
    constitutional     --low  
    HMMR loss resulted in a high percentage of multi-pole spindles in mitotic cells
    tumoral     --over  
    may contribute to the development of hormonal resistance in PCa (prostate adenocarcinoma)
    tumoral     --over  
    in the ossifying fibroma
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • RHAMM&
  • 8722;/&
    8722; mouse embryonic fibroblasts exhibit strongly acetylated interphase microtubules, multi-pole mitotic spindles, aberrant chromosome segregation, and inappropriate cytokinesis during mitosis