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FLASH GENE
Symbol HMMR contributors: mct/ - updated : 09-10-2013
HGNC name hyaluronan-mediated motility receptor (RHAMM)
HGNC id 5012
Location 5q34      Physical location : 162.887.516 - 162.918.949
Synonym name
  • intracellular hyaluronic acid binding protein
  • receptor for hyaluronan-mediated motility
  • CD168 antigen
  • Synonym symbol(s) RHAMM, IHABP, CD168, MGC119494, MGC119495
    DNA
    TYPE functioning gene
    STRUCTURE 31.43 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure cell cycle-dependent synthesis is controlled by its promoter on the transcriptional level
    MAPPING cloned Y linked   status provisional
    Map cen - D5S422 - HMMR - D5S621 /D5S423 - qter
    Physical map
    LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor FLJ31951 5q33.3 hypothetical protein FLJ31951 MGC10067 5q33.3 hypothetical protein MGC10067 IL12B 5q31.1-q33.1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ADRA1B 5q33.1 adrenergic, alpha-1B-, receptor TTC1 5q32-q33.2 tetratricopeptide repeat domain 1 KIAA1935 5q34 KIAA1935 protein FABP6 5q23-q35 fatty acid binding protein 6, ileal (gastrotropin) FLJ14166 5q34 hypothetical protein FLJ14166 C1QTNF2 5q33.3 C1q and tumor necrosis factor related protein 2 LOC63920 5q34 transposon-derived Buster3 transposase-like SLU7 5q34 step II splicing factor SLU7 PTTG1 5q35.1 pituitary tumor-transforming 1 FLJ21477 5q34 hypothetical protein FLJ21477 GABRB2 5q33.1-q34 gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRA6 5q33.1-q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GABRA1 5q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GABRG2 5q31.3-q33.2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 MRP63P6 5q34 mitochondrial ribosomal protein 63 pseudogene 6 CCNG1 5q32-q34 cyclin G1 LOC134492 5q34 similar to RIKEN cDNA 2700047N05 HMMR 5q33.3 hyaluronan-mediated motility receptor (RHAMM) MAT2B 5q34-q35.1 methionine adenosyltransferase II, beta LOC391844 5 similar to beta-tropomyosin LOC391845 5 similar to ribosomal protein S15 LOC391846 5 similar to 60S ribosomal protein L7 LOC134541 5q35.1 similar to Ten-m2 ODZ2 5q35.1 odd Oz/ten-m homolog 2 KIBRA 5q35.1 KIBRA protein RARS 5pter-q11 arginyl-tRNA synthetase
    RNA
    TRANSCRIPTS type messenger
    text five isoforms (58, 60, 64, 70, 84kDa) (Spicer)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3141 - 724 - 1996 8890751
    18 splicing 3144 - 725 - 1996 8890751
    15 - 2917 - 638 - 1996 8890751
    17 - 3096 - 709 - 1996 8890751
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines breast cancer cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an acidic coiled coil domain
  • N-terminal motif overlapping the defined hyaluronan binding domain
  • two microtubule-binding regions
  • C-terminal 728LKDENSQLKSEVSKL742 microtubule-binding site
  • HOMOLOGY
    interspecies homolog to C.elegans c14h10.2
    Homologene
    FAMILY
  • ACC family
  • CATEGORY adhesion , protooncogene , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • the N-terminus interacts with microtubules and a separate carboxy-terminal domain is required for centrosomal targeting
  • associated with the cytoskeleton, microtubules, centrosomes and the mitotic spindle
  • found in the cell nucleus, on interphase microtubules, mitotic spindles, centrosomes, and within mitochondria
  • distributed in both the cytoplasm and nucleus
  • localized to the microtubule cytoskeleton and along mitotic spindles
  • basic FUNCTION
  • cell surface receptor for hyaluronan, and a microtubule-associated intracellular hyaluronan binding protein involved in signal transduction via Src tyrosine kinase family
  • functioning in the maintenance of spindle integrity
  • playing an important role in maintenance of embryonic stem cells pluripotency, viability, and cell cycle control
  • playing a role already in S phase
  • oncogenic protein implicated in the progression of many cancers, including breast, acute myeloid leukemia, multiple myeloma, gastric, and prostate cancers
  • required for regulating stability of interphase and mitotic microtubules and this function resided in the C-terminal 728LKDENSQLKSEVSKL742 microtubule-binding site
  • control the structure of interphase and mitotic spindle microtubules and these effects are driven by MEK1/ERK1/2 kinase activity
  • has a predominant role in the cell cycle in immortalized cells (HCF)
  • ARPC5 and HMMR, in addition to PRKCA, were required for migration of neointimal smooth muscle cells
  • centrosomal protein that contributes to the stability of the mitotic spindle
  • may play a key role in the osteoblastic differentiation process
  • ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis
  • cell-surface receptor for hyaluronan that regulates embryonic stem cell pluripotency and differentiation
  • required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
  • CELLULAR PROCESS cell cycle
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • subunit of the HARC complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hayluronic acid
  • a direct interaction with microtubules and an association with dynein
  • interacting with CD44 (HMMR and CD44 act together in a hyaluronan-dependent autocrine mechanism to coordinate sustained signaling through ERK1,2, leading to high basal motility of invasive breast cancer cells)
  • interacts with the spindle assembly factors dynein and TPX2 (like TPX2, its expression is up-regulated during mitosis)
  • associates with both interphase and mitotic spindle microtubules by directly binding to alpha- and beta-tubulin through a highly conserved leucine zipper in its C- terminus
  • MTA1 transcriptionally stimulates expression of the hyaluronan-mediated motility receptor (HMMR) and consequently regulates cancer invasion and migratory function
  • DYNLL1 interacted with a spindle-microtubule-associated adaptor formed by FAM83D and HMMR via TQT motifs in FAM83D)
  • cell & other
    REGULATION
    repressed by TP53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlate with the malignant condition and might be linked to the increased or abnormal cell proliferation in human oral squamous cell carcinomas
    tumoral     --over  
    in breast cancer is predictive of poor clinical outcome
    constitutional     --low  
    HMMR loss resulted in a high percentage of multi-pole spindles in mitotic cells
    tumoral     --over  
    may contribute to the development of hormonal resistance in PCa (prostate adenocarcinoma)
    tumoral     --over  
    in the ossifying fibroma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • RHAMM&
  • 8722;/&
    8722; mouse embryonic fibroblasts exhibit strongly acetylated interphase microtubules, multi-pole mitotic spindles, aberrant chromosome segregation, and inappropriate cytokinesis during mitosis