Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HMGN5 contributors: mct - updated : 06-06-2013
HGNC name high mobility group nucleosome binding domain 5
HGNC id 8013
Location Xq21.1      Physical location : 80.369.199 - 80.457.441
Synonym name
  • nucleosomal binding protein 1
  • Synonym symbol(s) RP11-196G4.1, NBP-45, NSBP1
    DNA
    TYPE functioning gene
    STRUCTURE 88.24 kb     7 Exon(s)
    motif
    text structure AU rich element (ARE), retroposon sequences HAL1, HERV1, LIMB7 in exon 6 and 3' utr
    MAPPING cloned Y linked N status provisional
    Map cen - ATP7A - PGK1 PGK1 - NSBP1 - qter
    Authors King (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2126 31 282 - 2001 11161810
    - - - 1350 - - liver, kidney, pancreas 2001 11161810
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
     stromal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus a bipartite nuclear localization signal (NLS)
  • a HMG-14/17 signalure including the nucleosomal binding domain
  • an acidic C-terminal domain that differs among vertebrate species
  • HOMOLOGY
    interspecies homolog to murine Nsbp1
    intraspecies homolog to HMG14/17
    Homologene
    FAMILY
  • HMGN family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,nucleolus
    text
  • specifically targeted by its C-terminal domain to nucleosomes in euchromatin
  • basic FUNCTION
  • nucleosome binding protein that modulates the expression of prolactin gene family members most likely by inducing changes in chromatin structurev
  • nuclear protein which binds to nucleosomes via the nucleosomal binding domain, unfolds chromatin, and affects transcription
  • may play a critical role in the development of gliomas
  • nucleosome-binding architectural protein that affect the structure and function of chromatin
  • has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription
  • promotes the viability of bladder cancer cells through increased cell proliferation but not decreased apoptosis, and increases the invasion ability of metastatic bladder cancer cells through the upregulation of MMP9 activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with nucleosomes alters the compaction of cellular chromatin and in living cells, HMGN5 interacts with linker histones
  • interaction of HMGN5 with nucleosomes alters the compaction of cellular chromatin and that in living cells, NSBP1 interacts with linker histonesinteract with histone H1, reduce its chromatin residence time, and can induce large-scale chromatin decompaction in living cells
  • binds to nucleosomes and regulates gene transcription through chromatin remodeling
  • N-terminal domain of HMGN5 interacts with the C-terminal domain of TMPO and these proteins reciprocally alter their interaction with chromatin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral     --over  
    in both high-grade and low-grade glioma tissue samples compared with normal brain tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    NSBP1 RNAi as a novel therapeutic approach for bladder cancer
    cancerreproductiveprostate
    downregulation of HMGN5 gene can inhibit the proliferation of prostate cancer cells
    ANIMAL & CELL MODELS