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FLASH GENE
Symbol HMGCLL1 contributors: mct - updated : 22-03-2017
HGNC name 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
HGNC id 21359
Location 6p12.1      Physical location : 55.299.172 - 55.444.012
Synonym name
  • endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • Synonym symbol(s) DKFZP434G1411, bA418P12.1, er-cHL
    EC.number 4.1.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 144.84 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RN7SK 6pter-p25 RNA, 7SK, nuclear ICK 6p12.3-p11.2 intestinal cell (MAK-like) kinase FBXO9 6p12.3-p11.2 F-box only protein 9 GCM1 6p21-p12 glial cells missing homolog 1 (Drosophila) LOC389398 6 LOC389398 ELOVL5 6p21.1-p12.1 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOC391930 6 similar to ribosomal protein L31 LOC391931 6 similar to replication protein A3, 14kDa; replication protein A3 (14kD) GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1 C6orf142 6p12.2-p12.1 chromosome 6 open reading frame 142 TINAG 6p12-p11.2 tubulointerstitial nephritis antigen CLNS1B 6p12 chloride channel, nucleotide-sensitive, 1B LOC391933 6 similar to Transforming protein p21b (K-Ras 2B) (Ki-Ras) (c-K-ras) LOC221344 6p12.1 hypothetical LOC221344 LOC389399 6 LOC389399 C6orf143 6p12.1 chromosome 6 open reading frame 143 HCRTR2 6p11-q11 hypocretin (orexin) receptor 2 LOC389400 6 similar to IVFI9356 HMGCLL1 6p12.1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 LOC391934 6 similar to nitrogen fixation cluster-like BMP5 6p11.1 bone morphogenetic protein 5 COL21A1 6p12.3-p11.2 collagen, type XXI, alpha 1 LOC221341 6p12.1 similar to RCC1-like BPAG1 6p12-p11 bullous pemphigoid antigen 1, 230/240kDa C6orf65 6p12.1 chromosome 6 open reading frame 65 MRPL30P1 6p12.1 chromosome 6 open reading frame 65 KIAA1586 6p12.1 KIAA1586 ZNF451 6p12.1 zinc finger protein 451 BAG2 6p12.3-p11.2 BCL2-associated athanogene 2 RAB23 6p11.2-p12.3 RAB23, member RAS oncogene family PRIM2A 6p12-p11.1 primase, polypeptide 2A, 58kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2481 - 340 - 2012 22847177
    10 - 2571 - 370 - 2012 22847177
    6 - 2172 - 237 - 2012 22847177
    8 - 2385 - 308 - 2012 22847177
    10 - 2577 - 241 - 2012 22847177
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     intestinesmall intestineduodenum   Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal myristoylation motif
  • a HMGL-like region
  • lacks the peroxisomal targeting sequence C(K/R)L present in HMGCL
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • dual location in the endoplasmic reticulum (ER) and cytosol, but not in mitochondria or peroxisomes
  • basic FUNCTION
  • may have a catalytic activity
  • having metabolic function, mostly at the pulmonary and brain level
  • extramitochondrial hydroxymethylglutaryl-CoA lyase
  • may be an active, extramitochondrial HMG-CoA lyase and may be subject to post-translational myristoylation
  • plausible physiological roles for HMGCLL1 in either lipid biosynthesis and/or energy metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS