SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
|
| intracellular,nucleus,nucleolus
|
text
| in mitotic cells, free and associated with the condensed chromatin |
basic FUNCTION
| involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination |
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regulate various cellular activities, including transcription, DNA replication, and repair |
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with HMGB1, HMGB3, function as universal sentinels for nucleic acid |
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HMG2B potentiates GATA1-dependent transcription of GFI1B by POU5F1 and thereby controls erythroid differentiation |
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plays a significant role in tumor development and prognosis of hepatocellular carcinoma |
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HMGB1 and HMGB2 have critical roles in cellular processes, including transcription and DNA modification |
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HMGB1 and HMGB2 function redundantly to enhance WNT signaling in embryos |
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negatively regulated the stimulatory effect of WNT/CTNNB1 signaling on the RUNX2 proximal promoter |
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suppresses chondrogenic differentiation |
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its expression decreases with chondrocyte differentiation in growth plate but remains at high levels in bone marrow |
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necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and TP53-mediated downregulation is a critical mechanism of modulating HMGB2 expression |