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FLASH GENE
Symbol HMG20A contributors: mct - updated : 19-05-2016
HGNC name high-mobility group 20A
HGNC id 5001
Location 15q24.3      Physical location : 77.713.242 - 77.777.943
Synonym name
  • HMG domain-containing protein 1
  • HMG domain-containing protein HMGX1
    • Synonym symbol(s) FLJ10739HMGX1, HMGX1, HMGXB1, Ibraf
    DNA
    TYPE functioning gene
    STRUCTURE 64.95 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see TM6SF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4153 40.1 347 testis, heart, spleen highly 2000 10773667
    HMGX1
    10 - 3972 - 234 spleen, testis, leukocytes, brain 2000 10773667
    10 - 4060 40.1 347 weak expression 2000 10773667
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain    
     brainhindbraincerebellum  
     spinal cord    
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		two HMG box domains (conserved DNA binding domain)
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Hmg20a
    intraspecies paralog to HMG20B
    Homologene
    FAMILY HMG box family
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in the extension of neurite-type cytoplasmic processes in developing cells
  • its expression leads to the abrogation of REST-mediated transcriptional repression and the resultant activation of neuronal-specific genes
  • HMG-domain protein, having a key role in the initiation of neuronal differentiation, through recruitment of MLL
  • activates REST (RE-1 silencing transcription factor)-responsive genes, playing a key role in the initiation of neuronal differentiation
  • HMG20A can replace HMG20B and, therefore, they are mutually exclusive subunits of the complex
  • is essential for the mesenchymal phenotype
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HMG20B is able to form heterodimers with its homologous protein HMG20A
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with REST
  • direct interaction of beta-dystrobrevin(DTNB) with the HMG20 proteins HMG20A and HMG20B, suggesting that DTNB may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation
  • interplay between HMG20B and HMG20A controls the activity of the KDM1A–RCOR2 complex during neuronal differentiation
  • HMG20A together with KDM1A are required for SNAI1-dependent repression of epithelial genes and for TGFB1-triggered EMT
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS