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FLASH GENE
Symbol HMG20A contributors: mct - updated : 13-06-2012
HGNC name high-mobility group 20A
HGNC id 5001
Location 15q24.3      Physical location : 77.713.242 - 77.777.943
Synonym name
  • HMG domain-containing protein 1
  • HMG domain-containing protein HMGX1
    • Synonym symbol(s) FLJ10739HMGX1, HMGX1, HMGXB1, Ibraf
    DNA
    TYPE functioning gene
    STRUCTURE 64.70 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see TM6SF1
    Physical map
    FLJ38190 15q23-q24.1 hypothetical protein FLJ38190 ETFA 15q23-q25 electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) ISL2 15q23 ISL2 transcription factor, LIM/homeodomain, (islet-2) LOC388139 15 LOC388139 ZNF291 15q24 zinc finger protein 291 RCN2 15q22.33-q24.1 reticulocalbin 2, EF-hand calcium binding domain LOC390610 15 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 PSTPIP1 15q24-q25.1 proline-serine-threonine phosphatase interacting protein 1 TM4SF8 15q23 transmembrane 4 superfamily member 8 KIAA2002 15q24.1 KIAA2002 protein C15orf5 15q23-q24 chromosome 15 open reading frame 5 HMG20A 15q24 high-mobility group 20A LOC388140 15 LOC388140 FLJ14594 15q24.1 hypothetical protein FLJ14594 LOC342111 15q24.1 hypothetical gene supported by NM_001897 LOC388141 15 LOC388141 LOC390611 15 similar to hypothetical protein FLJ20452 KIAA1055 15q24.1 KIAA1055 protein LOC146013 15q24.1 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) KIP2 15q24.3 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) IDH3A 15q25.1-q25.2 isocitrate dehydrogenase 3 (NAD+) alpha BG1 15q24-q25 isocitrate dehydrogenase 3 (NAD+) alpha DNAJA4 15q24.1 DnaJ (Hsp40) homolog, subfamily A, member 4 REC14 15q24.1 recombination protein REC14 CRABP1 15q24 cellular retinoic acid binding protein 1 IREB2 15q24 iron-responsive element binding protein 2 LOC123688 15q24.1 similar to RIKEN cDNA C630028N24 gene PSMA4 15q24.1 proteasome (prosome, macropain) subunit, alpha type, 4 CHRNA5 15q24 cholinergic receptor, nicotinic, alpha polypeptide 5 CHRNA3 15q24 cholinergic receptor, nicotinic, alpha polypeptide 3 CHRNB4 15q24 cholinergic receptor, nicotinic, beta polypeptide 4 LOC390612 15 similar to ribosomal protein L18; 60S ribosomal protein L18 LOC388142 15 LOC388142
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3898 40.1 347 testis, heart, spleen highly 2000 10773667
    HMGX1
    - - - 9000 - - spleen, testis, leukocytes, brain 2000 10773667
    - - - 1500 - - weak expression 2000 10773667
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain    
     brainhindbraincerebellum  
     spinal cord    
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		two HMG box domains (conserved DNA binding domain)
    HOMOLOGY
    interspecies homolog to murine Hmg20a
    intraspecies paralog to HMG20B
    Homologene
    FAMILY HMG box family
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in the extension of neurite-type cytoplasmic processes in developing cells
  • its expression leads to the abrogation of REST-mediated transcriptional repression and the resultant activation of neuronal-specific genes
  • HMG-domain protein, having a key role in the initiation of neuronal differentiation, through recruitment of MLL
  • activates REST (RE-1 silencing transcription factor)-responsive genes, playing a key role in the initiation of neuronal differentiation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with REST
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS