basic FUNCTION
| involved in the basal expression of PAI1 |
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binding the myosin light chain enhancer and likely, many other targets |
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required for error-free postreplication repair of damaged DNA (in keeping with its cancer-suppression role) |
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actin-dependent regulator of chromatin structure |
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promotes PCNA polyubiquitination |
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playing a role in promoting RAD6A/RAD18- and UBE2V2-UE2N-dependent PCNA polyubiquitination (implicates its involvement in promoting error-free postreplication repair through DNA lesions) |
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can facilitate fork regression and has a role in replication of damaged DNA |
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promotes the restart of replication forks blocked at DNA lesions and can promote error-free replication of damaged DNA |
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may be preventing mutagenesis and carcinogenesis |
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modulates basal expression of SERPINE1 involved in regulation of cell migration |
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HLTF and SHPRH suppress mutagenesis in a damage-specific manner |
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HLTF and SHPRH may coordinate the two main branches of postreplication repair to choose the proper bypass mechanism for minimizing mutagenesis |
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exhibits ubiquitin ligase activity for proliferating cell nuclear antigen (PCNA) polyubiquitylation as well as double-stranded DNA translocase activity for remodeling stalled replication fork by fork reversal |
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has an ATP hydrolysis-dependent protein remodeling activity, by which it can remove proteins bound to the replication fork |
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crucial role for SMARCA3 in S100A10-dependent neurogenic and behavioral response to chronic antidepressant administration |
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is involved in a RAD51-independent D-loop branch of template switch pathway that can promote repair of gaps formed during replication of damaged DNA |
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regulates transcription, remodels chromatin, and coordinates DNA damage repair |
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regulates G2/M transition, WT1/GATA4/HIF1A cardiac transcription networks, and collagen biogenesis |