Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HLF contributors: SGE/npt - updated : 10-06-2010
HGNC name hepatic leukemia factor
HGNC id 4977
Corresponding disease
HLF acute lymphoblastic leukemia, preB-cell
Location 17q22      Physical location : 53.342.320 - 53.402.426
Synonym symbol(s) MGC33822
DNA
TYPE functioning gene
STRUCTURE 60.11 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC339209 17q22 hypothetical LOC339209 LOC124662 17q22 similar to phosphatidylinositol 4-kinase type II LOC388402 17 similar to 40S ribosomal protein S2 LOC84643 17q22 kinesin protein LOC390803 17 similar to KIAA2033 protein LOC124667 17q22 similar to hypothetical protein MGC4276 similar to CG8198 TOM1L1 22q13 target of myb1-like 1 (chicken) COX11 17q21.31-q23 COX11 homolog, cytochrome c oxidase assembly protein (yeast) STXBP4 17q22 syntaxin binding protein 4 HLF 17q22 hepatic leukemia factor MMD 17q monocyte to macrophage differentiation-associated LOC390804 17 similar to Glycyl-tRNA synthetase (Glycine--tRNA ligase) (GlyRS) LOC342599 17q23.1 similar to PEPD protein FLJ10970 17q23.1 hypothetical protein FLJ10970 PCTP 17q21-q22 phosphatidylcholine transfer protein FLJ38335 17q23.1-q23.2 hypothetical protein FLJ38335 LOC342600 17q23.2 similar to hypothetical protein 4932411E22 NOG 17q22 noggin DGKE 17q22 diacylglycerol kinase, epsilon 64kDa ZNF147 17q22 zinc finger protein 147 (estrogen-responsive finger protein) COIL 17q22-q23 coilin RISC 17q23.2 coilin LOC376412 17q23.2 ring finger protein 126 pseudogene AKAP1 17q21-q23 a kinase (PRKA) anchor protein 1 MSI2 17q23.1 musashi homolog 2 (Drosophila) FLJ11710 17q23.2 hypothetical protein FLJ11710 MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 5607 - 295 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BZIP domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Hlf (97.6pc)
    homolog to Rattus Rn.21134
    homolog to C.elegans K02F3.4
    Homologene
    FAMILY
  • bZIP family
  • PAR subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in the function of differnetiated neurons in the adult nervous system rather than programmed cell death (Hitzler 1999)
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer or heterodimer with other PAR factors
  • INTERACTION
    DNA
  • binding to double-stranded DNA
  • binding sequence-specific promoter elements to activate transcription
  • RNA
    small molecule
    protein
  • CSTF2 is central to the function of HLF and appears to be at least partly responsible for its cell cycle regulation
  • cell & other
    REGULATION
    activated by thyroid hormone receptor beta/retinoid X receptor alpha, and thus increasing HIF1A gene expression (Otto 2008)
    Other accumulating according to a robust circadian rythm
    ASSOCIATED DISORDERS
    corresponding disease(s) HLF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    rearranged in acute B-cell leukemia, with translocation t(17;19)(q22;p13) and fusion with TCF3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS