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FLASH GENE
Symbol HLF contributors: SGE/npt - updated : 10-06-2010
HGNC name hepatic leukemia factor
HGNC id 4977
Corresponding disease
HLF acute lymphoblastic leukemia, preB-cell
Location 17q22      Physical location : 53.342.320 - 53.402.426
Synonym symbol(s) MGC33822
DNA
TYPE functioning gene
STRUCTURE 60.11 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 5607 - 295 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BZIP domain
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Hlf (97.6pc)
    homolog to Rattus Rn.21134
    homolog to C.elegans K02F3.4
    Homologene
    FAMILY
  • bZIP family
  • PAR subfamily
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in the function of differnetiated neurons in the adult nervous system rather than programmed cell death (Hitzler 1999)
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer or heterodimer with other PAR factors
    • INTERACTION
    DNA
  • binding to double-stranded DNA
  • binding sequence-specific promoter elements to activate transcription
    • RNA
    small molecule
    protein
  • CSTF2 is central to the function of HLF and appears to be at least partly responsible for its cell cycle regulation
    • cell & other
    REGULATION
    activated by thyroid hormone receptor beta/retinoid X receptor alpha, and thus increasing HIF1A gene expression (Otto 2008)
    Other accumulating according to a robust circadian rythm
    ASSOCIATED DISORDERS
    corresponding disease(s) HLF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    rearranged in acute B-cell leukemia, with translocation t(17;19)(q22;p13) and fusion with TCF3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS