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FLASH GENE
Symbol HLA-E contributors: npt/ - updated : 23-05-2003
HGNC name major histocompatibility complex, class I, E
HGNC id 4962
Location 6p21.3      Physical location : 1.750.097 - 30.461.981
Synonym name
  • HLA class Ib
  • MHC class I antigen E
  • lymphocyte antigen
  • Synonym symbol(s) HLA-6.2, DKFZp686P19218, EA1.2, EA2.1, HLAE, MHC, QA1
    DNA
    TYPE functioning gene
    STRUCTURE 3.83 kb     8 Exon(s)
    text structure 6.2kb HindIII fragment
    MAPPING cloned Y linked N status confirmed
    Physical map
    ETF1P1 6p21.3 eukaryotic translation termination factor 1 pseudogene 1 C6orf12 6p22.1 chromosome 6 open reading frame 12 ZNRD1 6p21.3 zinc ribbon domain containing, 1 PPP1R11 6p21.3 protein phosphatase 1, regulatory (inhibitor) subunit 11 RNF39 6p21.3 ring finger protein 39 TRIM31 6p21.3 tripartite motif-containing 31 TRIM40 6p21.31 tripartite motif-containing 40 TRIM10 6p21.3 tripartite motif-containing 10 TRIM15 6p21.3 tripartite motif-containing 15 TRIM26 6p21.3 tripartite motif-containing 26 HLA-L 6p21.3 major histocompatibility complex, class I, L TRIM39 6p21.3 tripartite motif-containing 39 C6orf135 6p21.32 chromosome 6 open reading frame 135 MICC 6p21.3 MHC class I polypeptide-related sequence C LOC346173 6p21.32 similar to Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP-specific succinyl-CoA synthetase beta subunit) RANP1 6p21.32 RAN, member RAS oncogene family pseudogene 1 HLA-E 6p21.3 major histocompatibility complex, class I, E GNL1 6p21.3 guanine nucleotide binding protein-like 1 PRR3 6p21.32 proline-rich polypeptide 3 ABCF1 6p21.33 ATP-binding cassette, sub-family F (GCN20), member 1 PPP1R10 6p21.3 protein phosphatase 1, regulatory subunit 10 MRPS18B 6p21.3 mitochondrial ribosomal protein S18B C6orf134 6p21.32 chromosome 6 open reading frame 134 C6orf136 6p21.32 chromosome 6 open reading frame 136 DHX16 6p21.3 DEAH (Asp-Glu-Ala-His) box polypeptide 16 KIAA1949 6p21.3 KIAA1949 protein NRM 6p21.31 nurim (nuclear envelope membrane protein) MDC1 6pter-p21.3 mediator of DNA damage checkpoint 1 OK/SW-cl.56 6p21.32 beta 5-tubulin FLOT1 6p21.3 flotillin 1 IER3 6p21.3 immediate early response 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1701 38 358 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three globular extracellular domains, alpha 1 and alpha 2 forming the peptide binding groove
  • a I, C-like alpha 3 domain
  • a single transmembrane domain
  • a cytoplasmic tail
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • HLA, class I family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • harboring structural features conferring tight peptide binding specificity correlating with the binding of an MHC class I leader peptide
  • central immunotolerance role during early pregnancy, modulating cytokine production of monocyte-generated dendritic cells during early pregnancy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex
    text required for the development of pregnancy
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding a restricted subset of peptides derived from the leader peptides of other class I molecules
  • cell & other
    REGULATION
    Other TAP and tapasin dependent
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS