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FLASH GENE
Symbol HLA-E contributors: npt/ - updated : 23-05-2003
HGNC name major histocompatibility complex, class I, E
HGNC id 4962
Location 6p21.3      Physical location : 1.750.097 - 30.461.981
Synonym name
  • HLA class Ib
  • MHC class I antigen E
  • lymphocyte antigen
    • Synonym symbol(s) HLA-6.2, DKFZp686P19218, EA1.2, EA2.1, HLAE, MHC, QA1
    DNA
    TYPE functioning gene
    STRUCTURE 3.83 kb     8 Exon(s)
    text structure 6.2kb HindIII fragment
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1701 38 358 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three globular extracellular domains, alpha 1 and alpha 2 forming the peptide binding groove
  • a I, C-like alpha 3 domain
  • a single transmembrane domain
  • a cytoplasmic tail
    • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • HLA, class I family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • harboring structural features conferring tight peptide binding specificity correlating with the binding of an MHC class I leader peptide
  • central immunotolerance role during early pregnancy, modulating cytokine production of monocyte-generated dendritic cells during early pregnancy
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex
    text required for the development of pregnancy
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding a restricted subset of peptides derived from the leader peptides of other class I molecules
    • cell & other
    REGULATION
    Other TAP and tapasin dependent
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS