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FLASH GENE
Symbol HLA-DRB5 contributors: mct - updated : 26-08-2008
HGNC name major histocompatibility complex, class II, DR beta 5
HGNC id 4953
Location 6p21.3      Physical location : 32.485.162 - 32.498.006
Genatlas name HLA-DR, beta 5 chain, found in DR2 haplotypes
Synonym name MHC HLA-DR-beta cell surface glycoprotein
DNA
TYPE like-sequence
SPECIAL FEATURE head to head
STRUCTURE 12.00 kb     6 Exon(s)
MAPPING cloned   linked   status confirmed
Physical map
LOC389451 6 LOC389451 HLA-DRB9 6p21.3 major histocompatibility complex, class II, DR beta 9 (pseudogene) LOC391863 6 similar to Olfactory receptor 4F3 HLA-DRB5 6p21.3 major histocompatibility complex, class II, DR beta 5 LOC389356 6 similar to bA476I15.3 (novel protein similar to septin) HLA-DRB6 6p21.3 major histocompatibility complex, class II, DR beta 6 (pseudogene) HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 C6orf35 6q25.3 chromosome 6 open reading frame 35 LOC389357 6 LOC389357 DUSP22 6p24.3 dual specificity phosphatase 22 IRF4 6p25-p23 interferon regulatory factor 4 SEC5 LOC391990 6 similar to serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II HUS1B 6p25.3 HUS1 checkpoint homolog b (S. pombe) LOC340177 6q27 hypothetical LOC340177 LOC389452 6 LOC389452 LOC391991 6 similar to lysR-like transcriptional regulator LOC391992 6 similar to putative heavy metal transporter LOC391993 6 similar to F22G5.20 LOC391994 6 similar to Hypothetical protein FLJ30525 LOC221768 6p25.3 similar to ENSANGP00000010305 FOXQ1 6p25-p23 forkhead box Q1 LOC389358 6 LOC389358 FOXF2 6p25.3 forkhead box F2 LOC221766 6p25.3 hypothetical LOC221766 LOC389359 6 LOC389359 LOC389360 6 LOC389360 LOC389361 6 LOC389361 FOXC1 6p25 forkhead box C1 GMDS 6p25 GDP-mannose 4,6-dehydratase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1171 - 266 - Lacap (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunetonsils   highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION part of the major histocompatibility complex
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component Heterodimer of an alpha chain and a beta chain
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to chronic rheumatic valve disease
Variant & Polymorphism SNP protecting against chronic rheumatic valve disease
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS