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FLASH GENE
Symbol HLA-DQB1 contributors: - updated : 27-09-2004
HGNC name major histocompatibility complex, class II, DQ beta 1
HGNC id 4944
Corresponding disease
IDDM1 diabetes mellitus insulin-dependent 1
Location 6p21.3      Physical location : 3.906.294 - 32.634.466
Synonym name HLA-DQ,beta chain
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     5 Exon(s)
MAPPING cloned Y linked N status confirmed
Physical map
EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila) C6orf10 6p21.3 chromosome 6 open reading frame 10 BTNL2 6p21.3 butyrophilin-like 2 (MHC class II associated) HLA-DRA 6p21.3 major histocompatibility complex, class II, DR alpha HLA-DRB9 6p21.3 major histocompatibility complex, class II, DR beta 9 (pseudogene) HLA-DRB3 6p21.3 major histocompatibility complex, class II, DR beta 3 HLA-DRB2 6p21.3 major histocompatibility complex, class II, DR beta 2 HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 HLA-DQA1 6p21.3 major histocompatibility complex, class II, DQ alpha 1 HLA-DQB1 6p21.3 major histocompatibility complex, class II, DQ beta 1 HLA-DQA2 6p21.3 major histocompatibility complex, class II, DQ alpha 2 HLA-DQB2 6p21.3 major histocompatibility complex, class II, DQ beta 2 HLA-DOB 6p21.3 major histocompatibility complex, class II, DO beta TAP2 6p21.3 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) PSMB8 6p21.3 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) TAP1 6p21.3 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) PSMB9 6p21.3 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2) PPP1R2P1 6p21.31 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1 LOC389380 6 LOC389380 HLA-DMB 6p21.3 major histocompatibility complex, class II, DM beta HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) IDDM1
Susceptibility
  • IDDM1, SLE, MS
  • to celiac disease
    • Variant & Polymorphism other
  • allele DQ8-DR4/DQ2-DR3/DQ4-DR4
  • DRB11501/DRB10301/DQB10602/DQB10201 susceptibility for SLE
  • DRB1 1501/DQB1 0602 increases susceptibility to MS
  • DQB1 0201 increasing rhe rsk of celiac disease
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS