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FLASH GENE
Symbol HLA-DQB1 contributors: - updated : 27-09-2004
HGNC name major histocompatibility complex, class II, DQ beta 1
HGNC id 4944
Corresponding disease
IDDM1 diabetes mellitus insulin-dependent 1
Location 6p21.3      Physical location : 3.906.294 - 32.634.466
Synonym name HLA-DQ,beta chain
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     5 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) IDDM1
Susceptibility
  • IDDM1, SLE, MS
  • to celiac disease
  • Variant & Polymorphism other
  • allele DQ8-DR4/DQ2-DR3/DQ4-DR4
  • DRB11501/DRB10301/DQB10602/DQB10201 susceptibility for SLE
  • DRB1 1501/DQB1 0602 increases susceptibility to MS
  • DQB1 0201 increasing rhe rsk of celiac disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS