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FLASH GENE
Symbol HLA-DPB1 contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DP beta 1
HGNC id 4940
Corresponding disease
WG Wegener's granulomatosis
Location 6p21.3      Physical location : 4.276.210 - 33.054.976
Synonym name
  • HLA DP14-beta chain
  • beta1 domain MHC class II HLA DPB
  • MHC class II HLA-DP-beta-1
    • Synonym symbol(s) DPB1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 11.22 kb     6 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    regionally located approximatively 130kb telomeric to RXRB with significant desiquilibrium between RXRB and HLA-DPB1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1501 26.2 258 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular globular domains
  • alpha 1, alpha 2, a transmembranee segment
  • a cytoplasmic tail, highly polymorphic
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class II family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DPA1, forming the peptide groove between alpha 1 and beta 1 domains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WG
    Susceptibility
    Variant & Polymorphism other *0401 allele is strongly associated with WG in ANCA-positive subjects
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS