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FLASH GENE
Symbol HLA-DOA contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DO alpha
HGNC id 4936
Location 6p21.3      Physical location : 4.204.054 - 32.977.389
Synonym name
  • lymphocyte antigen
  • major histocompatibility complex, class II, DN alpha
  • MHC class II antigen DOA
  • Synonym symbol(s) HLA-DZA, HLA-DNA, HLA-D0-alpha, HLADZ
    DNA
    TYPE functioning gene
    STRUCTURE 5.43 kb     5 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Physical map
    HLA-DQA2 6p21.3 major histocompatibility complex, class II, DQ alpha 2 HLA-DQB2 6p21.3 major histocompatibility complex, class II, DQ beta 2 HLA-DOB 6p21.3 major histocompatibility complex, class II, DO beta TAP2 6p21.3 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) PSMB8 6p21.3 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) TAP1 6p21.3 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) PSMB9 6p21.3 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2) PPP1R2P1 6p21.31 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1 LOC389380 6 LOC389380 HLA-DMB 6p21.3 major histocompatibility complex, class II, DM beta HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2 HLA-DOA 6p21.3 major histocompatibility complex, class II, DO alpha HLA-DPA1 6p21.3 major histocompatibility complex, class II, DP alpha 1 HLA-DPB1 6p21.3 major histocompatibility complex, class II, DP beta 1 RPL32P1 6p21.3 ribosomal protein L32 pseudogene 1 LOC391913 6 similar to MHC HLA-SX-alpha HLA-DPB2 6p21.3 major histocompatibility complex, class II, DP beta 2 (pseudogene) COL11A2 6p21.3 collagen, type XI, alpha 2 RXRB 6p21.3 retinoid X receptor, beta SLC39A7 6p21.3 solute carrier family 39 (zinc transporter), member 7 HSD17B8 6p21.3 hydroxysteroid (17-beta) dehydrogenase 8 RING1 6p21.3 ring finger protein 1 VPS52 6p21.3 vacuolar protein sorting 52 (yeast) B3GALT4 6p21.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 RPS18 6p21.3 ribosomal protein S18 C6orf11 6p21.3 chromosome 6 open reading frame 11 D6S2723E 6p21.3 DNA segment on chromosome 6 (unique, pseudogene) 2723 expressed sequence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3485 25 250 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular globular domains, alpha 1, alpha2
  • a transmembrane segment
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • HLA-class II family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • acting as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DOB to form HLA-DO, forming the peptide groove between alpha 1 and beta 1 domains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HLA-DM
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS